McGorry is Professor of Youth Mental Health at the University of Melbourne. He has written numerous peer reviewed articles, published in journals including The Lancet, the British Journal of Psychiatry, the American Journal of Psychiatry and the Medical Journal of Australia. He is executive director of Orygen Youth Health  and founding editor of Early Intervention in Psychiatry published by the International Early Psychosis Association.
McGorry and his colleagues developed an approach for young people who have symptoms of psychosis for the first time, based at the EPPIC clinic in Melbourne. This EPPIC clinic has played a key part in an early psychosis treatment paradigm for psychiatry and has led to significant reform of mental health services, especially in the United Kingdom. The EPPIC clinic is best represented by the catch phrase "A stitch in time" and its development of a service for those at risk of developing psychosis. However, despite claims that EPPIC produces better outcomes than standard care, there has never been a comparison of EPPIC with either early or late mainstream treatment. It has been alleged that McGorry has "systematically misled" the Australian government about the nature and implications of his evaluation study on EPPIC by misstating the description of the control group. While more rigorous evaluations of early intervention services have been carried out in other countries, a systematic review of these studies concluded: "There is some support for specialised early intervention services, but further trials would be desirable, and there is a question of whether gains are maintained." McGorry has claimed that early intervention services can save money, but this has also been questioned by a recent review of the evidence. Professor McGorry was awarded the Centenary Medal in 2003 in recognition of his work on the EPPIC programme.
McGorry has advocated for early intervention with young people who are at risk of psychosis, but who are not currently psychotic, including the use of antipsychotic medication. His views have been criticised by a number of people, including Allen Frances the Chair of the DSM-IV Taskforce, on the basis that most at-risk young people will not become psychotic and pre-emptive treatment may be risky. McGorry and his colleagues have responded to this criticism, arguing that critics have blurred the key distinction between clinical recommendations and ethically approved research designed to build evidence to more firmly guide clinical practice.   A trial of the antipsychotic medication quetiapine, led by McGorry, attracted criticism on ethical grounds and was discontinued. More recently,[when?] McGorry has begun investigating the use of lower risk treatments such as fish oil.
McGorry has advocated to the Australian government to create a national network of early psychosis intervention centres, based on claims that early treatment may improve long-term outcomes. Some critics have argued that he has exaggerated the evidence for early intervention and that long-term benefits and economic savings have not been established. He has been accused of having a conflict of interest in using his position on a government advisory committee to advocate for programs that he founded. McGorry has denied that he has any conflict of interest. On 25 September 2012, Western Australian member of parliament Martin Whitely made a speech in parliament criticizing the Australian Federal Government for its support of McGorry's proposals. Whitely said that McGorry had made overblown claims for his programs and that they had been accepted without proper scrutiny.
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- McGorry PD; Edwards J; Mihalopoulos C; Harrigan SM; Jackson HJ (1996). "EPPIC: an evolving system of early detection and optimal management". Schizophrenia Bulletin 22 (2): 305–326. doi:10.1093/schbul/22.2.305. PMID 8782288. Retrieved 2009-02-14.
- Edwards, J. & McGorry, P.D. (2002) (eds). Implementing Early Intervention in Psychosis. A guide to establishing early psychosis services. London. Martin Dunitz.
- McGorry PD, Killackey EJ (2002). "Early intervention in psychosis: a new evidence based paradigm". Epidemiol Psichiatr Soc 11 (4): 237–47. PMID 12585014.
- McGorry PD, Killackey E, Yung A (October 2008). "Early intervention in psychosis: concepts, evidence and future directions". World Psychiatry 7 (3): 148–56. PMC 2559918. PMID 18836582.
- Killackey E, Yung AR, McGorry PD (2007). "Early psychosis: where we've been, where we still have to go". Epidemiol Psichiatr Soc 16 (2): 102–8. PMID 17619539.
- Joseph R, Birchwood M (September 2005). "The national policy reforms for mental health services and the story of early intervention services in the United Kingdom". J Psychiatry Neurosci 30 (5): 362–5. PMC 1197282. PMID 16151542.
- McGorry, P. D. (1998). ""A stitch in time"… the scope for preventive strategies in early psychosis". European Archives of Psychiatry and Clinical Neuroscience 248 (1): 22–31. doi:10.1007/s004060050014. PMID 9561350.
- Yung AR, McGorry PD, McFarlane CA, Jackson HJ, Patton GC, Rakkar A (1996). "Monitoring and care of young people at incipient risk of psychosis". Schizophr Bull 22 (2): 283–303. doi:10.1093/schbul/22.2.283. PMID 8782287.
- Raven, M. (2011). Evaluating evidence for Early Psychosis Prevention and Intervention Centres (EPPIC). The Conversation 2 November 2011. http://www.theconversation.edu.au/evaluating-evidence-for-early-psychosis-prevention-and-intervention-centres-eppic-3604
- Raven M. EPPIC mirage: cost-effectiveness of early psychosis intervention. Aust N Z J Psychiatry 2013; 47: 599-601.
- Marshall M, Rathbone J. Early intervention for psychosis" Cochrane Database of Systematic Reviews 2011, Issue 6. Art. No.: CD004718. doi:10.1002/14651858.CD004718.pub3
- Orygen Youth Health Research Centre (2011) Early Psychosis Feasibility Study. Canberra: National Advisory Council on Mental Health
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- McGorry, P.D. (2009). Intervention in individuals at ultra-high risk for psychosis: a review and future directions" Journal of Clinical Psychiatry 70, 1206-1212.
- Frances. A. (2010). Psychosis risk syndrome—far too risky? Australian and New Zealand Journal of Psychiatry, 45, 803-804.
- Dunlevy, S. (2011). US expert slams McGorry’s psychosis model. The Australian, 14 June 2011. http://www.theaustralian.com.au/national-affairs/us-expert-slams-patrick-mcgorrys-psychosis-model/story-fn59niix-1226074544901
- Jorm AF. Ethics of giving antipsychotic medication to at-risk young people. Aust N Z J Psychiatry. 2012 Sep;46(9) 908-9.
- McGorry, P (April 2012). "Truth and reality in early intervention". Australian and New Zealand Journal of Psychiatry 46 (4): 313–316. doi:10.1177/0004867412442172.
- McGorry, P (March 2012). "At issue: Cochrane, early intervention, and mental health reform: analysis, paralysis, or evidence-informed progress?". Schizophrenia Bulletin 38 (2): 221–224. doi:10.1093/schbul/sbr185. PMID 22247539.
- McGorry, P (July 2011). "Pre-emptive intervention in psychosis: agnostic rather than diagnostic". Australian and New Zealand Journal of Psychiatry 45 (7): 515–519. doi:10.3109/00048674.2011.581648. PMID 21718121. Retrieved 13 March 2013.
- Stark, J. (2011). Drug trial scrapped amid outcry. The Age, 21 August 2011. http://www.theage.com.au/national/drug-trial-scrapped-amid-outcry-20110820-1j3vy.html.
- Raven, M., Stuart, G.W. & Jureidini, J. (2012). ‘Prodromal’ diagnosis of psychosis: ethical problems in research and clinical practice. Australian and New Zealand Journal of Psychiatry, 46, 64-65.
- Vincent, M. (2011). Budget provides mental health relief. AM, 11 May 2011. http://www.abc.net.au/am/content/2011/s3213405.htm
- Creagh, S. (2011). Review finds limited evidence for early psychosis intervention centres. The Conversation,, 30 June 2011. http://theconversation.edu.au/review-finds-limited-evidence-for-early-intervention-in-psychosis-2091
- Bosanac, P., Patton, G.C. & Castle, D.J. (2010). Early intervention in psychotic disorders: faith before facts?" Psychological Medicine 40, 353-358.
- Amos, A. (2012). Assessing the cost of early intervention in psychosis: a systematic review. Australian & New Zealand Journal of Psychiatry 46, 719-734.
- Amos, A. (2013). An axeman in the cherry orchard: Early intervention rhetoric distorts public policy. Australian & New Zealand Journal of Psychiatry, 47, 317-320
- Stark, J. (2011). McGorry accused of conflict of interest. Sydney Morning Herald 7 August 2011. http://www.smh.com.au/national/mcgorry-accused-of-conflict-of-interest-20110806-1igxd.html
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- Dunlevy, S. (2012). Doubts cast on youth mental health program. Herald Sun 7 October 2012. http://www.heraldsun.com.au/news/national/doubts-cast-on-youth-mental-health-program/story-fndo48ca-1226489760605
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