Paul was the second vocalist with Exodus replacing Keith Stewart in 1981 and singing on their 1982 Demo and their first official album Bonded by Blood in 1985. After the release, they started the pre-production for their second album. Following the recording of a three song demo in 1986, Paul Baloff was dismissed from Exodus after "personal and musical differences", although he still had writer credits on their next album Pleasures of the Flesh.
After leaving Exodus, he sang in several bands in the San Francisco Bay area, such as Piranha,Hirax, and Heathen.
In 1997, when Exodus decided to reunite, Baloff was again invited to sing with the band.
In 2002, Paul Baloff suffered a stroke which left him in a coma and he was taken off life support by doctors. He was 41 years old. Following his death, Baloff's replacement in Exodus Steve Souza rejoined the band and sang on their 2004 album Tempo of the Damned, which is dedicated to Baloff's memory.