Du Bois contributed to the renewal of artistic expression in Belgium at the end of the 20th Century, and was one of the founders of the art group Les XX. His own eclectic work consists of small sculptures, medals, jewelry, fine art sculpture, public monuments, and tombs.
Among his most famous monumental works, located in Brussels, are the monument to Frederic de Merode, and the tribute to Edith Cavell and fellow nurse Marie Depage (of the RMS Lusitania), the Four Elements group in the Botanical Garden of Brussels, and several sculptures in the City of Saint-Gilles. He was also responsible for the design of the Victory Medal of World War I, of which 350,000 copies were issued. Many other monuments are erected on his hand and places in the cemeteries of Ixelles, from Uccle, Tournai, Mons, Frameries, Huy, and Liège. His works are also exhibited in the museums of different cities.