In 2009 he tore up Rookie League pitching for the Missoula Osprey, hitting .334 and 18 home runs along with 62 RBI in just half a season of pro ball, giving him (along with his college totals from earlier in the 2009 season) 36 HR and an incredible 150 RBI in only 131 games that year.
He continued his success the following year in the California League, where he was named an All-Star as well as the league's Most Valuable Player. He was also named the Arizona Diamondbacks Minor League Player of the Year. 2011 was just as impressive, as he was once again named the Diamondbacks Minor League Player of the Year, Baseball America 1st team Minor League All-Star, Double-A All-Star 1B, Southern League All-Star 1B, and Southern League Most Valuable Player.
In all, Goldschmidt hit .317 with a .407 on-base percentage and 83 home runs in only two and a half minor league seasons.
Goldschmidt was called up to the majors for the first time on August 1, 2011, becoming the first Texas State position player to play at the major league level. At the time of his call-up, he was leading the minors in home runs (30). In his first Major League at-bat, Goldschmidt had a base hit. The next day, on August 2, 2011, Goldschmidt hit his first home run off of San Francisco Giants pitcher Tim Lincecum. In his rookie season, Goldschmidt batted .250 with 8 home runs and 26 RBI in 48 games.
In Game 3 of the NLDS against the Brewers, Goldschmidt blasted a two-out grand slam to keep the Diamondbacks alive in the postseason. He is only the third rookie to hit a grand slam in post season history. The Diamondbacks lost the series in 5 games, but Goldschmidt batted .438 with 6 RBIs and an OBP of .526.
In 2012, Goldschmidt played in 145 games and batted .286 with 20 home runs, 82 runs, 82 RBIs, 43 doubles, and 18 stolen bases.
Goldschmidt hit his first career regular season grand slam on June 1 off of Chicago Cubs pitcher Carlos Marmol at Wrigley Field. Only four days later on June 5, Goldschmidt hit another grand slam, this time against St Louis Cardinals reliever Maikel Cleto. Goldshmidt hits his 3rd Grand Slam on August 20 against pitcher J.J. Hoover and the Reds to improve their lead to 5-0.
During the 2013 MLB season, Goldschmidt's performance earned him a spot on the National League All-Star team alongside teammate Patrick Corbin. Goldschmidt collected the only extra-base hit for the National League, a 2B to right center field with two outs in the 9th.
On August 13, Goldschmidt hit a game-tying home run against the Baltimore Orioles in the bottom of the ninth inning to send the game into extra innings. Goldschmidt then hit a walk-off home run in the bottom of the eleventh, becoming the first player in Arizona Diamondbacks history to record a decisive game-tying home run and walk-off home run in the same game.