|Sir Paul Nurse|
Paul Nurse in 2007
|Born||Paul Maxime Nurse
25 January 1949 
Norwich, Norfolk, England
|Thesis||The spatial and temporal organisation of amino acid pools in Candida utilis (1974)|
|Doctoral advisor||Tony Simms|
|Spouse||Anne Teresa Nurse (née Talbott)|
Sir Paul Maxime Nurse, PRS, HonFREng, PhD, (born 25 January 1949), is an English geneticist, President of the Royal Society and Chief Executive and Director of the Francis Crick Institute. He was awarded the 2001 Nobel Prize in Physiology or Medicine along with Leland Hartwell and Tim Hunt for their discoveries of protein molecules that control the division (duplication) of cells in the cell cycle.
Early life and education
Nurse's mother went from London to Norwich, Norfolk and lived with relatives while awaiting Paul's birth in order to hide illegitimacy. His biological maternal grandmother pretended to be his mother while she was alive and his mother pretended to be his sister for her entire life too. He was educated at Lyon Park school in Alperton and Harrow County Grammar School. His undergraduate applications were rejected by the Universities of Oxford, Cambridge, Sussex and York on account of the fact that he did not possess the requisite pass in a foreign language. He was also initially rejected by the University of Birmingham, however after attending an interview he was offered a place conditional on the fact that he take French classes in his first year. He received his undergraduate degree in 1970 from the University of Birmingham and his Doctor of Philosophy (Ph.D.) in 1973 from the University of East Anglia for research on Candida utilis.
Beginning in 1976, Nurse identified the gene cdc2 in yeast (Schizosaccharomyces pombe). This gene controls the progression of the cell cycle from G1 phase to S phase and the transition from G2 phase to mitosis. In 1987, Nurse identified the homologous gene in human, Cdk1, which codes for a cyclin dependent kinase.
When cells with nuclei divide, they divide in phases called G1 (growth), S (synthesis), G2 (growth), and M (mitosis). Nurse, Hartwell and Hunt together discovered two proteins, cyclin and cyclin dependent kinase (CDK), that control the transition from one stage to another. These proteins are called checkpoints, because they check whether the cell has divided properly. If the cell doesn't divide correctly, other proteins will attempt to repair it, and if unsuccessful, they will destroy the cell. If a cell divides incorrectly and survives, it can cause cancer and other serious diseases.
Working in yeast, Nurse identified the gene cdc2, which controls the transition from G1 to S, when the cell grows in preparation for the duplication of DNA, and G2 to M, when the cell divides. Nurse also found the corresponding gene, CDK1, in humans. These genes stop and start cyclin dependent kinase (CDK) by adding or removing phosphate groups.
In 1984, Nurse joined the Imperial Cancer Research Fund (ICRF, now Cancer Research UK). He left in 1988 to chair the department of microbiology at the University of Oxford. He then returned to the ICRF as Director of Research in 1993, and in 1996 was named Director General of the ICRF, which became Cancer Research UK in 2002. In 2003, he became president of Rockefeller University in New York City where he continues to work on the cell cycle of fission yeast. It was announced on 15 July 2010 that Nurse was to become the first Director and Chief Executive of the UK Centre for Medical Research and Innovation. He took up his post on 1 January 2011.
Awards and honours
In addition to the Nobel Prize, Nurse has received numerous awards and honours. In 1989, he was elected a Fellow of the Royal Society (FRS) and in 1995 he received a Royal Medal and became a foreign associate of the U.S. National Academy of Sciences. He received the Albert Lasker Award for Basic Medical Research in 1998. Nurse was knighted in 1999. He was awarded the French Legion d'Honneur in 2002. He was also awarded the Copley Medal in 2005. He was elected a Foreign Honorary Member of the American Academy of Arts and Sciences - one of the top honours - in April 2006. He is a member of the Advisory Council for the Campaign for Science and Engineering. Dr. Nurse is the 2007 recipient of the Hope Funds Award of Excellence in Basic Research. In 2013, he became the winner of the Albert Einstein World Award of Science conferred by the World Cultural Council. His nomination for the Royal Society reads:
|“||Distinguished for his studies of genes which regulate the cell cycle in fission yeast and higher organisms. He developed techniques for transformation, gene replacement and expression vectors in the fission yeast S. pombe. He identified two major controls in the cell cycle and he cloned and characterized genes inovolved in commitment to DNA synthesis or mitosis notably the 'start' gene cdc 2. He showed that cdc 2 encodes a protein kinase which is potentially regulated by phosphorylation. He identified, cloned and sequenced the human equivalent of cdc 2 and showed that its sequence is extensively conserved from yeasts to man.
Together with Maller and Lohka, he has now shown that purified preparations of the vertebrate cell-cycle regulator 'maturation promoting factor' contain the product encoded by the cdc 2 homologue.
Nurse has received many Honorary Degrees, including from the University of Bath in 2002, the University of Kent in 2012, the University of Warwick (Doctor of Science) and the University of Worcester (Doctor of Science) in 2013. He was also appointed as a HonFREng of the Royal Academy of Engineering in 2012.
Nurse is married to Anne Teresa (née Talbott) and has two daughters.
Nurse has criticized potential Republican party candidates for the US presidential nomination for opposing the teaching of natural selection, stem cell research on cell lines from human embryos, and anthropogenic climate change, even partially blaming scientists for not speaking up. He was alarmed that this could happen in the U.S., a world leader in science, "the home of Benjamin Franklin, Richard Feynman and Jim Watson."
One problem, Nurse said, was "treating scientific discussion as if it were political debate," using rhetorical tricks rather than logic. Another was the state of science teaching in the schools, which does not teach citizens how to discuss science - particularly in religious schools, even in the United Kingdom.
"We need to emphasise why the scientific process is such a reliable generator of knowledge with its respect for evidence, for skepticism, for consistency of approach, for the constant testing of ideas," wrote Nurse.
Finally, scientific leaders "have a responsibility to expose the bunkum," said Nurse. They should take on politicians, and expose nonsense during elections.
Nurse believes that scientists should speak out about science in public affairs and challenge politicians who support policies based on pseudoscience.
- "NURSE, Sir Paul (Maxime)". Who's Who 2014. Who's Who (online Oxford University Press ed.). A & C Black an imprint of Bloomsbury Publishing plc. (subscription required)
- Fisher, Daniel Leslie (1995). Molecular characterization of the fission yeast cyclin B homologue, cdc13 (DPhil thesis). University of Oxford.
- Labib, Karim (1993). Regulation of S-phase and mitosis in fission yeast (DPhil thesis). University of Oxford.
- MacNeill, Stuart Andrew (1990). Structural and functional analysis of the fission yeast p34cdc2 protein kinase (DPhil thesis). University of Oxford.
- Woollard, Alison (1995). Cell cycle control in fission yeast (DPhil thesis). University of Oxford.
- "EC/1989/23 Nurse, Sir Paul Maxime". London: The Royal Society. Archived from the original on 2014-09-03.
- "List of Fellows".
- Nurse, Paul Maxime (1974). The spatial and temporal organisation of amino acid pools in candida utilis (PhD thesis). University of East Anglia.
- Nurse, P (2012). "In answer to questions about the Francis Crick Institute". The Lancet 379 (9835): 2427–8. doi:10.1016/S0140-6736(12)61066-6. PMID 22748588.
- Nurse, P; Treisman, R; Smith, J (2013). "Building better institutions". Science 341 (6141): 10. doi:10.1126/science.1242307. PMID 23828914.
- Paul Nurse from the Scopus bibliographic database.
- The Nobel Prize in Physiology or Medicine 2001. Nobelprize.org.
- Paul Nurse on The Life Scientific in 2011, BBC
- "Autobiography of Paul Nurse". nobelprize.org. Retrieved 20 September 2012.
- Nurse, Paul. "Cyclin Dependent Kinases and Cell Cycle Control". nobelprize.org. Retrieved 20 September 2012.
- Nurse, P.; Thuriaux, P.; Nasmyth, K. (1976). "Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe". Molecular & general genetics : MGG 146 (2): 167–178. doi:10.1007/BF00268085. PMID 958201.
- Nurse, P. (2004). "Wee beasties". Nature 432 (7017): 557–557. doi:10.1038/432557a. PMID 15577889.
- Lee, M. G.; Nurse, P. (1987). "Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2". Nature 327 (6117): 31–35. doi:10.1038/327031a0. PMID 3553962.
- The Nobel Prize in Physiology or Medicine 2001 Illustrated Lecture
- "Project Press Release". UK Centre for Medical Research and Innovation web site. 15 July 2010. Retrieved 11 August 2010.
- "Advisory Council of the Campaign for Science and Engineering". Retrieved 2011-02-11.
- "World Cultural Council 30th Award Ceremony". Nanyang Technological University. 2 October 2013. Retrieved 2 October 2013.
- "Warwick honorary degrees for stars of Gavin & Stacey & Hustle, RSC & Royal Court Artistic Directors, scientists, historians, philanthropist & a US government adviser". University of Warwick. 28 June 2013. Retrieved 30 October 2013.
- "Worcester honorary degrees and Fellowships". University of Worcester. 21 November 2013. Retrieved 21 November 2013.
- Stamp out anti-science; it's time to reject political movements that turn their backs on science, Paul Nurse, New Scientist, 17 September 2011
- "Celebrities' open letter to Scotland – full text and list of signatories | Politics". theguardian.com. 2014-08-07. Retrieved 2014-08-26.
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|Wikiquote has quotations related to: Paul Nurse|
- Paul Nurse: Office of the President, Rockefeller University
- The Rockefeller University, Heads of Laboratories: Paul Nurse, Ph.D.
- Profile – Sir Paul Nurse[dead link] at BBC Four
- Dr Paul Nurse FRS – Cell division[dead link] from the Royal Society
- Paul Nurse[dead link] at Cancer Research UK
- Sir Paul Maxime Nurse[dead link] at Durham University
- Paul Nurse telling of discovering his personal heredity, World Science Festival, 12 June 2009.
- News media
- British Scientists (inc. Sir Paul Nurse) scoop 2001 Nobel Prize
- Sir Paul Nurse: Genetic identity cards for newborn children within 20 years[dead link]
- The Times Higher Education – Queen's Birthday Honours – Announcement of Paul Nurse becoming a Knight Bachelor
- A film clip "The Open Mind - A Vital Dialogue: Science and Its Paymasters (2007)" is available for free download at the Internet Archive [more]
- A film clip "The Open Mind - Are Scientists Keeping the Trust of the Public? (2006)" is available for free download at the Internet Archive [more]
- Interview with Sir Paul Nurse on career advice for people looking to get into Chemistry
- Lectures and publications
|President of Rockefeller University