Binder moved to London after the first world war and studied art at Central School of Art and Design. In this time Binder drew scenes from everyday life in London that she made into lithographs. She published a series that illustrated “The Real East End” by Thomas Burke, a popular writer who ran a pub in Poplar at the time. Binder's illustrations are an intimate, first-hand portrayal of grimy London life in that era.
In 1937 Binder was involved in the earliest days of television broadcasting for children. Also in 1937, she co-presented Clothes-Line with the fashion historian James Laver. This live six-part series was the first television programme on the history of fashion. As she did not give birth to her daughter Josephine until 6 January 1938 – less than a month after the last episode transmitted – Pearl Binder could well have been the first heavily pregnant woman to appear on television.
In the course of her life Binder travelled extensively in Russia and China, wrote a musical, designed costumes for a theatre company, wrote stories for children, designed a Pearly mug and plate for Wedgwood and instigated and executed 22 armorial windows at the House of Lords.