She was the vocalist of mid-1990s indie bands Powder and Lodger, which she fronted after a brief period at LAMDA, and as a solo-artist under the name Pearl. Throughout her music career, Lowe was nicknamed Pearl Spam by journalists in the NME.
In 2001 she launched 'Pearl Lowe', her signature range of lacecurtains and cushions. In 2006 Lowe started designing her own bespoke handmade dresses that sold exclusively for Libertys in London, she was quickly snapped up by the budget chain Peacocks where she designs a capsule range four times a year.
Lowe published her memoir All That Glitters in 2007, a sombre look at overcoming addiction.
Since 1995 her partner has been Supergrass drummer Danny Goffey, with whom she has three children, Alfie (born 1996), Frankie (born 1999) and Betty (born 2005). Goffey and Lowe married on December 4, 2008, in Babington House, Somerset.