Pemirolast

Pemirolast

Systematic (IUPAC) name
9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
Clinical data
Trade names	Alamast
AHFS/Drugs.com	monograph
Pregnancy cat.	C (US)
Legal status	℞ Prescription only
Routes	Oral, ophthalmic
Identifiers
CAS number	69372-19-6 Y
ATC code	None
PubChem	CID 57697
ChemSpider	51990 N
UNII	2C09NV773M N
KEGG	D07476 Y
ChEMBL	CHEMBL1201198 N
Chemical data
Formula	C10H8N6O
Mol. mass	228.21 g/mol
SMILES	eMolecules & PubChem
N (what is this?)  (verify)

Pemirolast (INN) is an anti-allergic drug. It is marketed under the tradenames Alegysal and Alamast.

It has also been studied for the treatment of asthma.

References

• Tinkelman DG, Berkowitz RB (February 1991). "A pilot study of pemirolast in patients with seasonal allergic rhinitis". Ann Allergy 66 (2): 162–5. PMID 1994787. 
• Kawashima T, Iwamoto I, Nakagawa N, Tomioka H, Yoshida S (1994). "Inhibitory effect of pemirolast, a novel antiallergic drug, on leukotriene C4 and granule protein release from human eosinophils". Int. Arch. Allergy Immunol. 103 (4): 405–9. doi:10.1159/000236662. PMID 8130655. 
• Abelson MB, Berdy GJ, Mundorf T, Amdahl LD, Graves AL (October 2002). "Pemirolast potassium 0.1% ophthalmic solution is an effective treatment for allergic conjunctivitis: a pooled analysis of two prospective, randomized, double-masked, placebo-controlled, phase III studies". J Ocul Pharmacol Ther 18 (5): 475–88. doi:10.1089/10807680260362759. PMID 12419098. 
• Kemp JP, Bernstein IL, Bierman CW, et al. (June 1992). "Pemirolast, a new oral nonbronchodilator drug for chronic asthma". Ann Allergy 68 (6): 488–91. PMID 1610024. 

External links

• Mitsubishi Tanabe Pharma Corporation (2007). "ALEGYSAL (English)". http://www.e-search.ne.jp/~jpr/PDF/MITSUB32.PDF. Retrieved 2008-09-02. 
• VISTAKON Pharmaceuticals, LLC (2005). "ALAMAST (pemirolast potassium opthalmic solution) 0.1%". http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=3230. Retrieved 2008-09-02.