Penitrem A

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Penitrem A
Penitrem A.png
Other names
12627-35-9 YesY
ChemSpider 298950 N
Jmol-3D images Image
PubChem 337313
Molar mass 634.20136
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Penitrem A (tremortin) is a fungal neurotoxin found on ryegrass. It is produced by certain species of Aspergillus, Claviceps, and Penicillium. It inhibits potassium channels in smooth muscles.[citation needed] The maxi-channels targeted have their highest density in the cerebellar Purkinje cells.

It causes a stagger in horses and cattle.

Effective dose[edit]

The ED50 for penitrem A is 10 nM.[citation needed] The ED50 is the effective dose for 50% of the population. Many toxic chemicals do not show ED-50s and act by irreversible covalent adduction.

Stages of toxicity[edit]

See also[edit]