The Wilkes-Barre Campus can trace its history to 1915 when two top engineers, who were affiliated with Penn State and worked in the coal industry, released a study on the growing need for additional engineers in the region. The next year, faculty from University Park began teaching night classes in the field at an area high school. Until the late 1940s, the school only offered evening courses in mechanical subjects. However, during this era, they began offering standard classes, and in 1953, they made available their first two full associate degrees.
In the mid-1960s, the school moved from its location in a hodgepodge of downtown Wilkes-Barre buildings to its current suburban campus.