Route 632 and Route 407 heading southbound through downtown Waverly
PA 407 begins at an intersection with US 6/US 11 in South Abington Township, Lackawanna County, heading north on two-lane undivided South Abington Road. The road heads through commercial areas and woods, turning north-northwest and passing under a viaduct carrying I-476 (Northeast Extension of the Pennsylvania Turnpike). The route heads into residential areas, becoming the border between Clarks Summit to the west and South Abington Township to the east. PA 407 becomes the border between Clarks Summit to the west and Clarks Green to the east before fully entering Clarks Green as it passes more homes, becoming North Abington Road. The road heads into Waverly Township and becomes Abington Road, heading through less dense residential areas with some woods and fields. The route heads through the community of Waverly, where it forms a short 2 block concurrency with PA 632.
PA 407 heads northeast into woodland with some fields and residences. The road enters North Abington Township and turns northwest as North Abington Road, passing through more rural areas. The route heads into forested areas of Lackawanna State Park and turns north, coming to an intersection with the western terminus of PA 524. PA 407 turns northwest and crosses Lake Lackawanna into Benton Township, turning north again and reaching a junction with PA 438 in the community of Wallsville. The road leaves the state park and heads through a mix of farmland and woodland with some homes, becoming an unnamed road and intersecting PA 107 in Fleetville. The route heads through more rural areas and passes through Kochners Corners, becoming Philadelphia-Great Bend Turnpike. PA 407 enters Lenox Township in Susquehanna County and becomes an unnamed road, crossing the East Branch Tunkhannock Creek and ending at an intersection with PA 374.
PA 407 was formerly called Main Street as it passed through the village of Waverly, having been changed in the early 2000's to Abington Road when house numbers were assigned in the village. Prior to 2004, PA 407 started at the intersection of State Street (US 6 and US 11) and Grove Street in Downtown Clarks Summit. It continued northward along East Grove Street for about one mile to the intersection of Abington Road, Grove Street, and Glenburn Road in Downtown Clarks Green. At this intersection, PA 407 turned left onto North Abington Road and continued on its present-day alignment. The realignment was recommended by an engineering study of the region and the Interstate 81 corridor in the early 2000's.