PA 756 begins as Ohio Street at an intersection with Pennsylvania Route 403 in the Moxham neighborhood of Johnstown. In Geistown Bentwood Avenue meets PA 756. PA 756 then makes a left turn onto Belmont Street. At the intersection with Bedford Street and Scalp Avenue, commonly known as the Geistown Cloverleaf, PA 756 makes a right turn. In Richland Township, PA 756 interchanges with US 219/PA 56. The eastern terminus is located in Elton, Adams Township at PA 160.