Pennsylvania Route 980 begins at US 22 in North Fayette Township. From North Fayette Township, it runs south to Venice where it meets PA 50. Route 980 then turns southeast towards Canonsburg. While passing through Cannonsburg, the road intersects Weavertown Road, which provides access to Exit 45 of I-79. After passing through Canonsburg, Route 980 abruptly ends at PA 519.