Pentagastrin

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Pentagastrin
Pentagastrin.png
Systematic (IUPAC) name
N-(isobutoxycarbonyl)-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Legal status ?
Pharmacokinetic data
Half-life 10 minutes or less
Identifiers
CAS number 5534-95-2 YesY
ATC code V04CG04
PubChem CID 9853654
IUPHAR ligand 870
DrugBank DB00183
ChemSpider 8029364 YesY
UNII EF0NX91490 YesY
KEGG D01631 YesY
ChEMBL CHEMBL1328 YesY
Synonyms (3S)-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}-3-[(2S)-2-[(2S)-3-(1H-indol-3-yl)-2-(3-{[(2-methylpropoxy)carbonyl]amino}propanamido)propanamido]-4-(methylsulfanyl)butanamido]propanoic acid
Chemical data
Formula C37H49N7O9S 
Mol. mass 767.893 g/mol
 YesY (what is this?)  (verify)

Pentagastrin (trade name Peptavlon) is a synthetic polypeptide that has effects like gastrin when given parenterally.[1] It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.

Pentagastrin binds to the cholecystokinin-B receptor, which is expressed widely in the brain. Activation of these receptors activates the phospholipase C second messenger system. When given intravenously it causes panic attacks.

Pentagastrin is also used as a stimulation test to elevate serotonin levels and cause symptoms of carcinoid syndrome. It provokes flushing and is useful in evaluating patients who describe flushing, but have normal or only marginally elevated biochemical markers for carcinoid syndrome. In addition, it has been used to stimulate ectopic gastric mucosa for the detection of Meckels diverticulum by nuclear medicine.

Pentagastrin's IUPAC chemical name is "L-Phenylalaninamide, N-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl".

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