Trade names Nipent
Protein binding 4%
Half-life 2.6 to 16 hours, mean 5.7 hours
C 11 H 16 N 4 O 4
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Pentostatin (or deoxycoformycin, trade name Nipent, manufactured by SuperGen) is an anticancer chemotherapeutic drug. [1 ]
Mechanism [ edit ]
It is classified as a
purine analog, which is a type of antimetabolite.
It mimics the
nucleoside adenosine and thus inhibits the enzyme adenosine deaminase, interfering with the cell's ability to process DNA. [2 ]
Cancer cells generally divide more often than healthy cells; DNA is highly involved in cell division ( mitosis) and drugs which target DNA-related processes are therefore more toxic to cancer cells than healthy cells.
Pentostatin is used to treat
hairy cell leukemia. It is given by [3 ] intravenous infusion once every two weeks for three to six months.
Additionally, pentostatin has been used to treat steroid-refractory acute and chronic
graft-versus-host disease. [4 ]
Pentostatin is also used in
chronic lymphocytic leukemia (CLL) patients who have relapsed.
References [ edit ]
^ Kay NE, Geyer SM, Call TG et al. (January 2007). "Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia". Blood 109 (2): 405–11. doi: 10.1182/blood-2006-07-033274. PMC 1785105. PMID 17008537.
^ Sauter C, Lamanna N, Weiss MA (September 2008). "Pentostatin in chronic lymphocytic leukemia". Expert Opin Drug Metab Toxicol 4 (9): 1217–22. doi: 10.1517/17425255.4.9.1217. PMID 18721115.
^ Cannon T, Mobarek D, Wegge J, Tabbara IA (October 2008). "Hairy cell leukemia: current concepts". Cancer Invest. 26 (8): 860–5. doi: 10.1080/07357900801965034. PMID 18798068.
^ Bolaños-Meade J, Jacobsohn DA, Margolis J, Ogden A, Wientjes MG, Byrd JC, Lucas DM, Anders V, Phelps M, Grever MR, Vogelsang GB (April 2005). "Pentostatin in steroid-refractory acute graft-versus-host disease". J Clin Onc 23 (12): 2661–8. doi: 10.1200/JCO.2005.06.130. PMID 15837980.