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Pepo may refer to:

  • Pepo (film), a 1935 Armenian film made by Hamo Beknazarian
  • Pepo, a modified berry with a hard outer rind
  • Pepo (jurist), an 11th-century law teacher at the University of Bologna
  • Pepo, born René Ríos Boettiger, a Chilean cartoonist, who used Pepo as a pseudonym
  • Pepo Mill., a synonym of the genus Cucurbita