Peptide transporter 1

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Solute carrier family 15 (oligopeptide transporter), member 1
Symbols SLC15A1 ; HPECT1; HPEPT1; PEPT1
External IDs OMIM600544 MGI1861376 HomoloGene38006 ChEMBL: 4605 GeneCards: SLC15A1 Gene
RNA expression pattern
PBB GE SLC15A1 207254 at tn.png
PBB GE SLC15A1 211349 at tn.png
More reference expression data
Species Human Mouse
Entrez 6564 56643
Ensembl ENSG00000088386 ENSMUSG00000025557
UniProt P46059 Q9JIP7
RefSeq (mRNA) NM_005073 NM_053079
RefSeq (protein) NP_005064 NP_444309
Location (UCSC) Chr 13:
99.34 – 99.4 Mb
Chr 14:
121.46 – 121.51 Mb
PubMed search [1] [2]

Peptide transporter 1 (PepT 1) also known as solute carrier family 15 member 1 (SLC15A1) is a protein that in humans is encoded by SLC15A1 gene.[1][2] PepT 1 is a solute carrier for oligopeptides. It functions in renal oligopeptide reabsorption and in the intestines in a proton dependent way, hence acting like a cotransporter.[3]


SLC15A1is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs.[1][3]

See also[edit]


  1. ^ a b "Entrez Gene: SLC15A1 Solute carrier family 15 (oligopeptide transporter), member 1". 
  2. ^ Liang R, Fei YJ, Prasad PD, Ramamoorthy S, Han H, Yang-Feng TL, Hediger MA, Ganapathy V, Leibach FH (March 1995). "Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization". J. Biol. Chem. 270 (12): 6456–63. doi:10.1074/jbc.270.12.6456. PMID 7896779. 
  3. ^ a b Adibi SA (July 1997). "The oligopeptide transporter (Pept-1) in human intestine: biology and function". Gastroenterology 113 (1): 332–40. doi:10.1016/S0016-5085(97)70112-4. PMID 9207295. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.