Peptidylprolyl isomerase A

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Peptidylprolyl isomerase A (cyclophilin A)
Protein PPIA PDB 1ak4.png
PDB rendering based on 1ak4.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PPIA ; CYPA; CYPH; HEL-S-69p
External IDs OMIM123840 MGI3648545 HomoloGene134504 IUPHAR: 2751 ChEMBL: 1949 GeneCards: PPIA Gene
EC number
Species Human Mouse
Entrez 5478 268373
Ensembl ENSG00000196262 ENSMUSG00000062933
UniProt P62937 P17742
RefSeq (mRNA) NM_001300981 NM_008907
RefSeq (protein) NP_001287910 NP_032933
Location (UCSC) Chr 7:
44.84 – 44.86 Mb
Chr 11:
6.42 – 6.42 Mb
PubMed search [1] [2]

Peptidylprolyl isomerase A also known as cyclophilin A or rotamase A is an enzyme that in humans is encoded by the PPIA gene.[1][2][3]


This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.[1]


Peptidylprolyl isomerase A has been shown to interact with ITK.[4]

See also[edit]


  1. ^ a b "Entrez Gene: PPIA peptidylprolyl isomerase A (cyclophilin A)". 
  2. ^ Haendler B, Hofer E (July 1990). "Characterization of the human cyclophilin gene and of related processed pseudogenes". Eur. J. Biochem. 190 (3): 477–82. doi:10.1111/j.1432-1033.1990.tb15598.x. PMID 2197089. 
  3. ^ Holzman TF, Egan DA, Edalji R, Simmer RL, Helfrich R, Taylor A, Burres NS (February 1991). "Preliminary characterization of a cloned neutral isoelectric form of the human peptidyl prolyl isomerase cyclophilin". J. Biol. Chem. 266 (4): 2474–9. PMID 1989998. 
  4. ^ Brazin, Kristine N; Mallis Robert J; Fulton D Bruce; Andreotti Amy H (Feb 2002). "Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (4): 1899–904. doi:10.1073/pnas.042529199. ISSN 0027-8424. PMC 122291. PMID 11830645. 

Further reading[edit]