Percocet

From Wikipedia, the free encyclopedia

Jump to: navigation, search
Percocet
Combination of
Oxycodone Opioid Analgesic
Acetaminophen Anilide Analgesic
Identifiers
CAS number  ?
ATC code  ?
PubChem  ?
Therapeutic considerations
Licence data

US FDA:link
Pregnancy cat.

?
Legal status

Schedule II(US)
Routes Oral

Percocet is a trademarked, potent compound painkiller used to treat moderately severe to severe acute (short-term) pain. The main ingredient of Percocet is oxycodone, a potent opioid agonist; in addition, the drug contains paracetamol, also known as acetaminophen. It is notable for its potential for drug abuse.

Contents

[edit] History

The U.S. Food and Drug Administration first approved Percocet in 1976, under application ANDA 085106.[1]

[edit] Pharmacology

Endo Pharmaceuticals currently manufactures Percocet, as well as Percodan which contains oxycodone and aspirin.[2] Percocet tablets are available in six combinations of oxycodone hydrochloride and acetaminophen, with different appearances and maximum daily doses:[2]

  • 2.5 mg oxycodone HCl & 325 mg acetaminophen: pink oval tablet, maximum daily dose 12 tablets
  • 5 mg oxycodone HCl & 325 mg acetaminophen: blue round tablet, maximum daily dose 12 tablets
  • 7.5 mg oxycodone HCl & 325 mg acetaminophen: peach oval tablet, maximum daily dose 8 tablets
  • 7.5 mg oxycodone HCl & 500 mg acetaminophen: peach capsule-shaped tablet, maximum daily dose 8 tablets
  • 10 mg oxycodone HCl & 325 mg acetaminophen: yellow capsule-shaped tablet, maximum daily dose 6 tablets
  • 10 mg oxycodone HCl & 650 mg acetaminophen: yellow oval tablet, maximum daily dose 6 tablets

For the 2.5 mg oxycodone HCl tablet, the usual dose is 1-2 tablets every six hours as needed for pain; for the other tablets, the usual dose is 1 tablet every six hours as needed for pain.[2]

Watson Laboratories manufactures generic versions of five of the six types of Percocet tablets (with 5, 7.5, and 10 mg oxycodone HCl).[3]

[edit] Abuse

Because it contains oxycodone, Percocet is a Schedule II drug under the Controlled Substances Act of the U.S.[4]

[edit] Paracetamol/Acetaminophen Deaths

On Jun 30 2009 an FDA advisory panel recommended that Percocet and another painkiller, Vicodin be removed from the market because they have allegedly caused over 400 deaths a year. The problem is with paracetamol overdose and liver damage.


Well-known people who have abused Percocet include:

  • In 1994 Cindy McCain, wife of Senator John McCain, admitted having been addicted to Percocet and Vicodin in the early 1990s, and to "[stealing] the drugs from her own nonprofit medical relief organization."[5]
  • Model Niki Taylor began abusing Percocet in the late 1990s after the death of her sister and the "breakup of her marriage."[6]

[edit] In popular culture

  • The title character on the show Nurse Jackie uses Percocet, ostensibly to deal with a bad back. It is implied that she is abusing it to cope with the stresses of her job and family life.

[edit] References

  1. ^ "Drugs@FDA. FDA approved drug products (searchable database)". U.S. Food and Drug Administration, Center for Drug Evaluation and Research. http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm. Retrieved on 2009-03-30. 
  2. ^ a b c "Percocet® oxycodone and acetaminophen tablets USP". Endo Pharmaceuticals. 2006 November. http://www.endo.com/pdf/products/Percocet_pack_insert_4.pdf. Retrieved on 2009-03-30. 
  3. ^ "Oxycodone and acetaminophen tablets USP". Watson Laboratories, Inc. 2008 May. http://pi.watson.com/data_stream.asp?product_group=1293&p=pi&language=E. Retrieved on 2009-03-30. 
  4. ^ "Controlled substances in alphabetical order". U.S. Drug Enforcement Administration. http://www.deadiversion.usdoj.gov/schedules/alpha/alphabetical.htm. Retrieved on 2009-03-30. 
  5. ^ Silverman, Amy (1999-10-18). "How Cindy McCain was outed for drug addiction". Salon.com. http://www.salon.com/news/feature/1999/10/18/drugs/. Retrieved on 2009-03-30. 
  6. ^ Dennis, Alicia (2009-01-19). "Model Niki Taylor 'I never thought i'd get pregnant again'". People Weekly. http://www.people.com/people/archive/article/0,,20252118,00.html. Retrieved on 2009-03-30. 
Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
Retrieved from "http://en.wikipedia.org/wiki/Percocet"
Personal tools