Oxycodone/paracetamol

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Oxycodone/paracetamol
Combination of
Oxycodone Opioid analgesic
Paracetamol Anilide analgesic
Clinical data
Trade names Percocet
AHFS/Drugs.com entry
Licence data US FDA:link
Pregnancy cat. C
Legal status Schedule II (US)
Routes Oral
Identifiers
CAS number 330988-72-2 YesY
ATC code ?
ChemSpider 4881971 YesY
 YesY (what is this?)  (verify)

The combination oxycodone/paracetamol (North American trade name Percocet, generic endocet and ratio-oxycocet in Canada) is a narcotic pain reliever used to treat moderate to severe acute (short-term) pain, marketed by Endo Pharmaceuticals.[1] It is regulated as a schedule 2 narcotic by the Drug Enforcement Agency (DEA) of the United States.

History[edit]

The U.S. Food and Drug Administration first approved Percocet in 1976, under application ANDA 085106.[2]

Formulation[edit]

As of March 2006, Endo Pharmaceuticals produces Percocet in following dosages.[3] Percocet tablets are available in six combinations of oxycodone hydrochloride and acetaminophen, with different appearances and maximum daily doses:[3]

Oxycodone Hydrochloride (mg) Acetaminophen (mg) Tablet Color Tablet Shape Maximum Daily Dose
2.5 325 pink oval 12 tablets
5 325 white round 12 tablets
7.5 325 peach oval 8 tablets
7.5 500 peach capsule-shaped 8 tablets
10.0 325 white oblong 8 tablets
10.0 650 yellow oval 6 tablets

For the 2.5 mg Oxycodone HCl tablet, the usual dose is 1–2 tablets every six hours as needed for pain; for the other tablets, the usual dose is 1-2 tablets every four to six hours as needed for pain.

Implicated in deaths[edit]

On June 30, 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with narcotic analgesics[4] be limited in their sales because of their contributions to an alleged 400 acetaminophen related deaths in the United States each year, that were attributed to acetaminophen overdose and associated liver damage.[5]

In December 2009, the Canadian Medical Association Journal reported a study finding a fivefold increase in oxycodone-related deaths in Ontario (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related Ontario deaths over the same period.[6][7][8]

See also[edit]

References[edit]

  1. ^ http://www.endo.com/pdf/products/Percocet_pack_insert_2.pdf
  2. ^ "Drugs@FDA. FDA approved drug products (searchable database)". U.S. Food and Drug Administration, Center for Drug Evaluation and Research. Retrieved 2009-03-30. 
  3. ^ a b "Percocet oxycodone and acetaminophen tablets USP". Endo Pharmaceuticals. May 2011. Retrieved October 20, 2012. 
  4. ^ http://www.webmd.com/pain-management/news/20090701/fda-may-restrict-acetaminophen
  5. ^ Harris, Gardiner (2009-07-01). "Ban Is Advised on 2 Top Pills for Pain Relief". The New York Times. Retrieved 2010-05-22. 
  6. ^ Irfan A. Dhalla, Muhammad M. Mamdani, Marco L.A. Sivilotti, Alex Kopp, Omar Qureshi, David N. Juurlink. Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone. Canadian Medical Association Journal, 2009; 181 (12): 891 DOI: 10.1503/cmaj.090784
  7. ^ Benedikt Fischer, Jürgen Rehm. Deaths related to the use of prescription opioids. Canadian Medical Association Journal, 2009; Fischer, B.; Rehm, J. (2009). "Deaths related to the use of prescription opioids". Canadian Medical Association Journal 181 (12): 881–882. doi:10.1503/cmaj.091791. PMC 2789122. PMID 19969577.  edit
  8. ^ Canadian Medical Association Journal (2009, December 7). Deaths from opioid use have doubled; five-fold increase in oxycodone deaths. ScienceDaily. Retrieved May 31, 2012, from http://www.sciencedaily.com/releases/2009/12/091207123105.htm

External links[edit]