Perflubron

From Wikipedia, the free encyclopedia
  (Redirected from Perfluorooctyl bromide)
Jump to: navigation, search
Perflubron
Perflubron structure.svg
Systematic (IUPAC) name
1-Bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane
Clinical data
Legal status ?
Identifiers
CAS number 423-55-2
ATC code V08CX01
PubChem CID 9873
ChemSpider 9489
ChEMBL CHEMBL1200866
Chemical data
Formula C8BrF17 
Mol. mass 498.96 g/mol
Physical data
Density 1.93 g/cm³
Melt. point 6 °C (43 °F)
Boiling point 142 °C (288 °F)

Perflubron (INN/USAN, or perfluorooctyl bromide) is a contrast medium for magnetic resonance imaging, computer tomography and sonography.[1] It has also been used in liquid breathing in premature infants with respiratory distress.[2][3]

See also[edit]

This molecular model of Perflubron is color-coded by electron density to illustrate the positive polarisation of the large bromine atom by the inductively electron-withdrawing perfluorooctyl chain.

References[edit]

  1. ^ Mattrey, R. F. (1989). "Perfluorooctylbromide: A new contrast agent for CT, sonography, and MR imaging". AJR. American journal of roentgenology 152 (2): 247–252. doi:10.2214/ajr.152.2.247. PMID 2643258.  edit
  2. ^ Wolfson, M. R.; Kechner, N. E.; Roache, R. F.; Dechadarevian, J. P.; Friss, H. E.; Rubenstein, S. D.; Shaffer, T. H. (1998). "Perfluorochemical rescue after surfactant treatment: Effect of perflubron dose and ventilatory frequency". Journal of applied physiology (Bethesda, Md. : 1985) 84 (2): 624–640. PMID 9475875.  edit
  3. ^ Leach, C. L.; Greenspan, J. S.; Rubenstein, S. D.; Shaffer, T. H.; Wolfson, M. R.; Jackson, J. C.; Delemos, R.; Fuhrman, B. P. (1996). "Partial Liquid Ventilation with Perflubron in Premature Infants with Severe Respiratory Distress Syndrome". New England Journal of Medicine 335 (11): 761–767. doi:10.1056/NEJM199609123351101. PMID 8778584.  edit