Periannan Senapathy is a molecular biologist and genome researcher. He is president and scientific director of Genome Life Sciences, a Genome International company in Madison, Wisconsin, which develops next-generation DNA sequencing technologies.
Before becoming president of Genome Life Sciences, Senapathy worked for the National Institutes of Health's Division of Computer Research and Technology in Bethesda, Maryland, and the Biotechnology Center of the University of Wisconsin, Madison.
Senapathy has observed that the reading-frame lengths in a random nucleotide sequence follow an exponential distribution, and has suggested the split-gene model, in which the most primitive unicellular eukaryotes a selective pressure existed to generate longer coding sequences and random sequences that were populated with in-frame nonsense codons, and intervened between short reading frames, started to be excised by an already existing spliceosome. This model proposes not only that the sequences excised contained random clusters of in-frame nonsense codons but also that the splice junction signal sequences and the branchpoint sequence originate from nonsense codons.
Independent Birth of Organisms
Senapathy published a book titled Independent Birth of Organisms in 1994, he claimed in the book that all organisms on earth had originated independently from a number of chemical ponds, thus rejecting common descent Senapathy claimed that the book was the result of 12 years research in molecular biology.
Andrew Petto of University of Wisconsin reviewed Senapathy's book saying that even though Senapathy had written a book arguing for natural origins, that the first half of Senapathy's book read like a typical creationist treatise with arguments based on gaps in the fossil record and the mention of mutations to descredit evolutionary biology. However Petto also said: "If the read manages to survive the first 199 pages of anti-evolutionary diatribe, however, there are a couple of interesting ideas in this book". Petto further explained that Senapathy has some very interesting views about the origins of life, such as his interpretation of the primordial soup theory and that these ideas should be taken seriously by the reader.
- Regulapati, R.; Bhasi, A.; Singh, C.K.; Senapathy, P. (2008). "Origination of the Split Structure of Spliceosomal Genes from Random Genetic Sequences". PLoS ONE 3: 10. doi:10.1371/journal.pone.0003456. PMC 2565106. PMID 18941625.
- Senapathy, P. (1995). "Introns and the origin of protein-coding genes". Science 268 (5215): 1366–7. doi:10.1126/science.7761858. PMID 7761858.
- Harris, N.L.; Senapathy, P. (1990). "Distribution and consensus of branch point signals in eukaryotic genes: a computerized statistical analysis". Nucleic Acids Res. 18 (10): 3015–9. doi:10.1093/nar/18.10.3015. PMC 330832. PMID 2349097.
- Senapathy, P. (1988). "Possible evolution of splice-junction signals in eukaryotic genes from stop codons". Proc Natl Acad Sci U S A. 85 (4): 1129–33. doi:10.1073/pnas.85.4.1129. PMC 279719. PMID 3422483.
- Senapathy, P. (1986). "Origin of eukaryotic introns: a hypothesis, based on codon distribution statistics in genes, and its implications". Proc Natl Acad Sci U S A. 83 (7): 2133–7. doi:10.1073/pnas.83.7.2133. PMC 323245. PMID 3457379.
- Shapiro, M.B.; Senapathy, P. (1986). "Automated preparation of DNA sequences for publication". Nucleic Acids Res. 14 (1): 65–73. doi:10.1093/nar/14.1.65. PMC 339356. PMID 3753793.
- Kamath, M. V. The United States and India, 1776-1996. Indian Council for Cultural Relations, 1998, p. 311.
- Genome Technologies LLC
- Review of Senapathys theory in Nucleic acids research, Volume 23, Issues 1-3, Information Retrieval Limited., 1995
- "A long explanation for introns", New Scientist, June 26, 1986.
- "Exon, introns, and evolution", New Scientist, March 31, 1988.
- Francesco, Catania et al. (September–October 2009). "Endogenous Mechanisms for the Origins of Spliceosomal Introns". Journal of Heredity 100 (5): 591–596. doi:10.1093/jhered/esp062. PMC 2877546. PMID 19635762. Retrieved 2011-05-01.
- Biology digest, Volume 15, Plexus Pub., 1988, p. 107
- Review of Independent Birth of Organisms, Nucleic acids research, Volume 23, Issues 1-3, Information Retrieval Limited., 1995, p. 312
- The United States and India, 1776-1996 Indian Council for Cultural Relations, 1998, p. 311.
- Independent Birth of Organisms reviewed by Andrew J. Petto, Department of Anthropology, University of Wisconsin, National Center for Science Education, Issue 37, Winter 1995 Online Edition