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Systematic (IUPAC) name
Clinical data
Legal status
Routes Oral
Pharmacokinetic data
Metabolism Hepatic (mostly via conjugation)[1]
Half-life 12 h[1]
Excretion Renal[1]
CAS number 2622-26-6 YesY
ATC code N05AC01
PubChem CID 4747
DrugBank DB01608
ChemSpider 4585 N
UNII 3405M6FD73 YesY
KEGG D01485 YesY
Chemical data
Formula C21H23N3OS 
Molecular mass 365.49 g/mol
 N (what is this?)  (verify)

Periciazine (INN), also known as pericyazine (BAN) or propericiazine, is a drug that belongs to the phenothiazine class of typical antipsychotics.

Pericyazine is not approved for sale in the United States. It is commonly sold in Canada under the tradename Neuleptil and in United Kingdom and Australia under the tradename Neulactil.[2]

Medical Uses[edit]

The primary uses of pericyazine include in the short-term treatment of severe anxiety or tension and in the maintenance treatment of psychotic disorders such as schizophrenia.[1]

Periciazine has also been studied in the treatment of opioid dependence.[3]

Adverse effects[edit]

Pericyazine is a rather sedating and anticholinergic antipsychotic, and despite being classed with the typical antipsychotics, its risk of extrapyramidal side effects is comparatively low.[4] It has a relatively high risk of causing hyperprolactinaemia and a moderate risk of causing weight gain and orthostatic hypotension.[4]


  1. ^ a b c d "NEULACTIL PRODUCT INFORMATION" (PDF). TGA eBusiness Services. sanofi-aventis australia pty ltd. 13 September 2011. Retrieved 2 November 2013. 
  2. ^ Pericyazine. Martindale: The Complete Drug Reference (The Royal Pharmaceutical Society of Great Britain). 23 September 2011. Retrieved 2 November 2013. 
  3. ^ Sivolap IuP, Savchenkov VA (1999). "[The use of neuroleptics in treating opiate dependence]". Zh Nevrol Psikhiatr Im S S Korsakova (in Russian) 99 (6): 29–34. PMID 10441864. 
  4. ^ a b "Approximate relative frequency (not intensity) of common adverse effects of antipsychotics (Table 8.21) [NB1]". eTherapeutic Guidelines complete. Therapeutic Guidelines Limited. February 2013. Retrieved 2 November 2013. 

External links[edit]