|Sinusoid of a rat liver with fenestrated endothelial cells. Fenestrae are approx 100 nm diameter, and the sinusoidal width 5 µm. Scanning electron micrograph by Robin Fraser, University of Otago.|
|Basic liver structure|
The perisinusoidal space (or space of Disse) is a location in the liver between a hepatocyte and a sinusoid. It contains the blood plasma. Microvilli of hepatocytes extend into this space, allowing proteins and other plasma components from the sinusoids to be absorbed by the hepatocytes. Fenestration and discontinuity of the endothelium facilitates this transport. This space may be obliterated in liver disease, leading to decreased uptake by hepatocytes of nutrients and wastes (like bilirubin, for example).
The Space of Disse also contains Ito cells, also called hepatic stellate cells, which store fat or fat soluble vitamins (like vitamin A). A variety of insults that cause inflammation can result in Ito cells transforming to myofibroblasts, resulting in collagen production, fibrosis, and cirrhosis.
- Robbins, Stanley L.; Cotran, Ramzi S.; Kumar, Vinay; Collins, Tucker (1999). Robbins pathologic basis of disease. Philadelphia: Saunders. ISBN 0-7216-7335-X.
- Haubrich WS (2004). "Disse of the space of Disse". Gastroenterology 127 (6): 1684. doi:10.1053/j.gastro.2004.10.021. PMID 15578505.
- UIUC Histology Subject 1317
- BU Histology Learning System: 22103loa - "Ultrastructure of the Cell: hepatocytes and sinusoids, sinusoid and space of Disse"
- BU Histology Learning System: 15204loa - "Liver, Gall Bladder, and Pancreas: liver; sinusoids and Kupffer cells"
- Organology at UC Davis digestive/mammal/liver5/liver7 - "Mammal, liver (EM, Low)"
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