Peroxiredoxin 1

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Peroxiredoxin 1
Protein PRDX1 PDB 1qq2.png
PDB rendering based on 1qq2.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PRDX1 ; MSP23; NKEF-A; NKEFA; PAG; PAGA; PAGB; PRX1; PRXI; TDPX2
External IDs OMIM176763 MGI99523 HomoloGene99789 ChEMBL: 5315 GeneCards: PRDX1 Gene
EC number 1.11.1.15
RNA expression pattern
PBB GE PRDX1 208680 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5052 18477
Ensembl ENSG00000117450 ENSMUSG00000028691
UniProt Q06830 P35700
RefSeq (mRNA) NM_001202431 NM_011034
RefSeq (protein) NP_001189360 NP_035164
Location (UCSC) Chr 1:
45.98 – 45.99 Mb
Chr 4:
116.69 – 116.7 Mb
PubMed search [1] [2]

Peroxiredoxin-1 is a protein that in humans is encoded by the PRDX1 gene.[1][2]

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Three transcript variants encoding the same protein have been identified for this gene.[2]

Interactions[edit]

Peroxiredoxin 1 has been shown to interact with PRDX4.[3]

References[edit]

  1. ^ Prosperi MT, Ferbus D, Karczinski I, Goubin G (June 1993). "A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins". J Biol Chem 268 (15): 11050–6. PMID 8496166. 
  2. ^ a b "Entrez Gene: PRDX1 peroxiredoxin 1". 
  3. ^ Jin, D Y; Chae H Z, Rhee S G, Jeang K T (December 1997). "Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation". J. Biol. Chem. (UNITED STATES) 272 (49): 30952–61. doi:10.1074/jbc.272.49.30952. ISSN 0021-9258. PMID 9388242. 

Further reading[edit]