Peroxiredoxin 1

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Peroxiredoxin 1
Protein PRDX1 PDB 1qq2.png
PDB rendering based on 1qq2.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PRDX1 ; MSP23; NKEF-A; NKEFA; PAG; PAGA; PAGB; PRX1; PRXI; TDPX2
External IDs OMIM176763 MGI99523 HomoloGene99789 ChEMBL: 5315 GeneCards: PRDX1 Gene
EC number 1.11.1.15
RNA expression pattern
PBB GE PRDX1 208680 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5052 18477
Ensembl ENSG00000117450 ENSMUSG00000028691
UniProt Q06830 P35700
RefSeq (mRNA) NM_001202431 NM_011034
RefSeq (protein) NP_001189360 NP_035164
Location (UCSC) Chr 1:
45.98 – 45.99 Mb
Chr 4:
116.69 – 116.7 Mb
PubMed search [1] [2]

Peroxiredoxin-1 is a protein that in humans is encoded by the PRDX1 gene.[1][2]

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Three transcript variants encoding the same protein have been identified for this gene.[2]

Interactions[edit]

Peroxiredoxin 1 has been shown to interact with PRDX4.[3] A chemoproteomic approach has revealed that peroxiredoxin 1 is the main target of theonellasterone.[4]

Clinical Significance[edit]

As enzymes that combat oxidative stress, peroxiredoxins play an important role in health and disease.[5] Peroxiredoxin 1 and peroxiredoxin 2 have been shown to be released by some cells when stimulated by LPS or TNF-alpha.[6] The released peroxiredoxin can then act to produce inflammatory cytokines.[6] The levels of peroxiredoxin 1 are elevated in pancreatic cancer and it can potentially act as a marker for the diagnosis and prognosis of this disease.[7] In some types of cancer, peroxiredoxin 1 has been determined to act as a tumor suppressor and other studies show that peroxiredoxin 1 is overexpressed in certain human cancers.[8] A recent study has found that peroxiredoxin 1 may play a role in tumorigenesis by regulating the mTOR/p70S6K pathway in esophageal squamous cell carcinoma.[8] The expression patterns of peroxiredoxin 1 along with peroxiredoxin 4 are involved in human lung cancer malignancy.[9] It has also been shown that peroxiredoxin 1 may be an important player in the pathogenesis of acute respiratory distress syndrome because of its role in promoting inflammation.[10]

References[edit]

  1. ^ Prosperi MT, Ferbus D, Karczinski I, Goubin G (June 1993). "A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins". J Biol Chem 268 (15): 11050–6. PMID 8496166. 
  2. ^ a b "Entrez Gene: PRDX1 peroxiredoxin 1". 
  3. ^ Jin, D Y; Chae H Z; Rhee S G; Jeang K T (December 1997). "Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation". J. Biol. Chem. (UNITED STATES) 272 (49): 30952–61. doi:10.1074/jbc.272.49.30952. ISSN 0021-9258. PMID 9388242. 
  4. ^ Margarucci, L; Monti, M. C.; Tosco, A; Esposito, R; Zampella, A; Sepe, V; Mozzicafreddo, M; Riccio, R; Casapullo, A (2015). "Theonellasterone, a steroidal metabolite isolated from a Theonella sponge, protects peroxiredoxin-1 from oxidative stress reactions". Chem. Commun 51 (9): 1591–3. doi:10.1039/c4cc09205h. PMID 25503482.  edit
  5. ^ El Eter, E; Al-Masri, A. A. (2015). "Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus". Brazilian Journal of Medical and Biological Research 0: 0. doi:10.1590/1414-431X20144142. PMID 25742636.  edit
  6. ^ a b Mullen, L; Hanschmann, E. M.; Lillig, C. H.; Herzenberg, L. A.; Ghezzi, P (2015). "Cysteine Oxidation Targets Peroxiredoxins 1 and 2 for Exosomal Release through a Novel Mechanism of Redox-Dependent Secretion". Molecular medicine (Cambridge, Mass.). doi:10.2119/molmed.2015.00033 (inactive 2015-04-02). PMID 25715249.  edit
  7. ^ Cai, C. Y.; Zhai, L. L.; Wu, Y; Tang, Z. G. (2015). "Expression and clinical value of peroxiredoxin-1 in patients with pancreatic cancer". European Journal of Surgical Oncology (EJSO) 41 (2): 228–35. doi:10.1016/j.ejso.2014.11.037. PMID 25434328.  edit
  8. ^ a b Gong, F; Hou, G; Liu, H; Zhang, M (2015). "Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma". Medical Oncology 32 (2): 455. doi:10.1007/s12032-014-0455-0. PMID 25579166.  edit
  9. ^ Jiang, H; Wu, L; Mishra, M; Chawsheen, H. A.; Wei, Q (2014). "Expression of peroxiredoxin 1 and 4 promotes human lung cancer malignancy". American journal of cancer research 4 (5): 445–60. PMC 4163610. PMID 25232487.  edit
  10. ^ Liu, D; Mao, P; Huang, Y; Liu, Y; Liu, X; Pang, X; Li, Y (2014). "Proteomic analysis of lung tissue in a rat acute lung injury model: Identification of PRDX1 as a promoter of inflammation". Mediators of Inflammation 2014: 469358. doi:10.1155/2014/469358. PMC 4082880. PMID 25024510.  edit

Further reading[edit]