Peroxiredoxin 2

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Peroxiredoxin 2
Protein PRDX2 PDB 1qmv.png
PDB rendering based on 1qmv.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PRDX2 ; HEL-S-2a; NKEF-B; NKEFB; PRP; PRX2; PRXII; PTX1; TDPX1; TPX1; TSA
External IDs OMIM600538 MGI109486 HomoloGene21182 GeneCards: PRDX2 Gene
EC number 1.11.1.15
RNA expression pattern
PBB GE PRDX2 39729 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7001 21672
Ensembl ENSG00000167815 ENSMUSG00000005161
UniProt P32119 Q61171
RefSeq (mRNA) NM_005809 NM_011563
RefSeq (protein) NP_005800 NP_035693
Location (UCSC) Chr 19:
12.91 – 12.91 Mb
Chr 8:
84.97 – 84.97 Mb
PubMed search [1] [2]

Peroxiredoxin-2 is a protein that in humans is encoded by the PRDX2 gene.[1][2]

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 2.7 angstroms. Transcript variants encoding distinct isoforms have been identified for this gene.[2]

References[edit]

  1. ^ Pahl P, Berger R, Hart I, Chae HZ, Rhee SG, Patterson D (Aug 1995). "Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12". Genomics 26 (3): 602–6. doi:10.1016/0888-7543(95)80183-M. PMID 7607688. 
  2. ^ a b "Entrez Gene: PRDX2 peroxiredoxin 2". 

Further reading[edit]