Norbert Perrimon

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Norbert Perrimon
Born (1958-10-24) October 24, 1958 (age 55) [1]
Bosguérard-de-Marcouville [1]
Citizenship France, USA
Nationality France
Alma mater University of Paris
Thesis Analyse Clonale de Mutations en Lignee Germinale chez la Drosophile (9183)
Academic advisors Madeleine Gans
Doctoral students Michele Musacchio, Rich Binari, John Klingensmith, Kang Zhang, Michael Melnick, Kenneth Yoffe, Yohannes Bellaiche, Urte Gayko, Markus Schober, Adam Friedman, Julio Cesar Cho, Michael Schnall-Levin, Tyler Gibson
Known for GAL4/UAS system
Notable awards George W. Beadle Award (2004)[2]

Norbert Perrimon (b. Oct. 24, 1958) is a geneticist and developmental biologist at Harvard Medical School. He is known for developing a number of techniques for use of Drosophila, as well as specific substantive contributions to signal transduction and developmental biology. Perrimon co-developed, with Andrea Brand are the GAL4/UAS system method to control gene expression[3] described as “a fly geneticist's Swiss army knife”.[4] More recently his lab has pioneered high-throughput whole-genome RNAi screening.[5][6][7][8][9][10]


Perrimon was born in 1958 in Bosguérard-de-Marcouville, France. He earned his undergraduate degree (Maitrise of Biochemistry) at the University of Paris VI, in 1981, then completing his doctorate in 1983 with Madeleine Gans also at the University of Paris.


From 1983 to 1986 Perrimon was a postdoctoral researcher with Anthony Mahowald[11][12][13][14] at Case Western Reserve University, and in 1986 at the age of 27 he accepted appointment as faculty at Harvard Medical School.

Awards and honors[edit]

Perrimon was elected to the United States National Academy of Sciences in April 2013,[6][15] after naturalizing as an American citizen.


  1. ^ a b
  2. ^ a b Schüpbach, T. (2004). "The 2004 George W. Beadle Medal". Genetics 166 (2): 649–650. doi:10.1534/genetics.166.2.649. PMC 1470725. PMID 15020455. 
  3. ^ Brand, A. H.; Perrimon, N. (1993). "Targeted gene expression as a means of altering cell fates and generating dominant phenotypes". Development (Cambridge, England) 118 (2): 401–415. PMID 8223268. 
  4. ^ Shetty, P. (2008). "Molecular biologist Andrea Brand: encouraging women in science". The Lancet 371 (9617): 979–979. doi:10.1016/S0140-6736(08)60439-0. 
  5. ^ Perrimon, N. (2005). "Norbert Perrimon". Current biology : CB 15 (13): R481–R482. doi:10.1016/j.cub.2005.06.050. PMID 16059997. 
  6. ^ a b Ravindran, S (2014). "Profile of Norbert Perrimon". Proceedings of the National Academy of Sciences 111 (21): 7501–2. doi:10.1073/pnas.1406464111. PMC 4040556. PMID 24778217. 
  7. ^ Perrimon, N; Gans, M (1983). "Clonal analysis of the tissue specificity of recessive female-sterile mutations of Drosophila melanogaster using a dominant female-sterile mutation Fs(1)K1237". Developmental biology 100 (2): 365–73. doi:10.1016/0012-1606(83)90231-2. PMID 6418585. 
  8. ^ Perrimon, N (1984). "Clonal Analysis of Dominant Female-Sterile, Germline-Dependent Mutations in DROSOPHILA MELANOGASTER". Genetics 108 (4): 927–39. PMC 1224274. PMID 17246244. 
  9. ^ White, R. A.; Perrimon, N; Gehring, W. J. (1984). "Differentiation markers in the Drosophila ovary". Journal of embryology and experimental morphology 84: 275–86. PMID 6442733. 
  10. ^ Perrimon, N.; Engstrom, L.; Mahowald, A. P. (1984). "The effects of zygotic lethal mutations on female germ-line functions in Drosophila". Developmental Biology 105 (2): 404. doi:10.1016/0012-1606(84)90297-5. 
  11. ^ Perrimon, N; Engstrom, L; Mahowald, A. P. (1985). "Developmental genetics of the 2C-D region of the Drosophila X chromosome". Genetics 111 (1): 23–41. PMC 1202596. PMID 3928431. 
  12. ^ Perrimon, N; Mohler, D; Engstrom, L; Mahowald, A. P. (1986). "X-linked female-sterile loci in Drosophila melanogaster". Genetics 113 (3): 695–712. PMC 1202863. PMID 3089870. 
  13. ^ Perrimon, N; Mahowald, A. P. (1986). "L(1)hopscotch, A larval-pupal zygotic lethal with a specific maternal effect on segmentation in Drosophila". Developmental biology 118 (1): 28–41. doi:10.1016/0012-1606(86)90070-9. PMID 3095163. 
  14. ^ Perrimon, N; Mahowald, A. P. (1987). "Multiple functions of segment polarity genes in Drosophila". Developmental biology 119 (2): 587–600. doi:10.1016/0012-1606(87)90061-3. PMID 3803719. 
  15. ^ "April 30, 2013, NAS Election", National Academy of Sciences (last visited May 3, 2013).