Pertactin

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Pertactin
Pertactin1bad.png
Bordetella pertussis Virulence Factor P.69 Pertactin. PDB entry 1dab[1]
Identifiers
Symbol PRN
Pfam PF03212
InterPro IPR004899
PROSITE PDOC00271
SCOP 1dab
SUPERFAMILY 1dab

In molecular biology, Pertactin (PRN) is a highly immunogenic virulence factor of Bordetella pertussis, a bacterium that causes pertussis. Specifically, it is an outer membrane protein that promotes adhesion to tracheal epithelial cells. PRN is purified from Bordetella pertussis and is used for the vaccine production as one of the important components of acellular pertussis vaccine.[2]

A large part of the N-terminus of the Pertactin protein is composed of beta helix repeats.[3] This region of the pertactin protein is secreted through the C-terminal autotransporter.

References[edit]

  1. ^ Emsley, P.; Charles, I. G.; Fairweather, N. F.; Isaacs, N. W. (1996). "Structure of Bordetella pertussis virulence factor P.69 pertactin". Nature 381 (6577): 90–92. doi:10.1038/381090a0. PMID 8609998.  edit
  2. ^ Poolman JT, Hallander HO (February 2007). "Acellular pertussis vaccines and the role of pertactin and fimbriae". Expert Rev Vaccines 6 (1): 47–56. doi:10.1586/14760584.6.1.47. PMID 17280478. 
  3. ^ Emsley P, Charles IG, Fairweather NF, Isaacs NW (May 1996). "Structure of Bordetella pertussis virulence factor P.69 pertactin". Nature 381 (6577): 90–2. doi:10.1038/381090a0. PMID 8609998.