DeBusk was born and raised in Rose Hill, Virginia, where he graduated from Thomas Walker High School. After graduating from Lincoln Memorial University, DeBusk began his career in 1965 as a pharmaceutical salesman and regional sales manager. In 1973 DeBusk patented his first medical product, an orthopedic boot, and founded DeRoyal Industries.
As the chairman of the Lincoln Memorial University Board of Trustees and a member of MedPAC Commission, DeBusk co-founded the Lincoln Memorial University DeBusk College of Osteopathic Medicine in 2007. The Lincoln Memorial University- John J. Duncan, Jr. School of Law, also co-founded by Debusk, was subsequently denied provisional accreditation by the American Bar Association. However, in the Fall of 2015, the law school received provisional accreditation from the American Bar Association. 
- Official WebsiteDeRoyal Executives
- Katie Porterfield, DeRoyal Treatment, Business TN, April 2008
- Spoke Public Records
- Genera Energy
- All Business, A D&B CompanyPublication:Business Wire June 3, 2003
- Lincoln Memorial University Official WebsiteAbout LMU-DCOM 2010