|Peter J. Hotez|
May 5, 1958|
|Fields||Vaccinology, Neglected Tropical Disease Control, Public Policy, Global Health|
|Institutions||Baylor College of Medicine, Texas Children's Hospital, Sabin Vaccine Institute, James Baker Institute|
|Alma mater||Rockefeller University (Ph.D.)|
Dr. Peter J. Hotez is a scientist, pediatrician, and leading advocate and expert in the fields of global health, vaccinology, and neglected tropical disease control. He serves as founding dean of the Baylor College of Medicine National School of Tropical Medicine, chief of the new Section of Tropical Medicine in the BCM Department of Pediatrics and holds the Texas Children’s Hospital Endowed Chair in Tropical Pediatrics. He is also President of the Sabin Vaccine Institute, headquartered in Washington, DC; and leads the Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development. Recently, he was named the Fellow in Disease and Poverty at Baker Institute for Public Policy at the Rice University.
- 1 Neglected Tropical Disease (NTD) Vaccine Research and Development ('the antipoverty vaccines')
- 2 Neglected Tropical Disease Policy and Advocacy
- 3 Blue Marble Health
- 4 National School of Tropical Medicine at Baylor College of Medicine
- 5 Biography and Education
- 6 Awards and Memberships
- 7 Publications and Media
- 8 Personal
- 9 References
- 10 External links
Neglected Tropical Disease (NTD) Vaccine Research and Development ('the antipoverty vaccines')
As President of the Sabin Vaccine Institute and Director of its product development partnership (PDP) Hotez leads an international team of scientists working to develop vaccines to combat hookworm infection, schistosomiasis, and other infectious and neglected diseases, including Chagas disease, leishmaniasis, and SARS. These diseases are the most common infections of the world’s poorest people.
Together with Philip K. Russell, Hotez founded the Human Hookworm Vaccine Initiative (HHVI) in 1999, the first initiative of the Sabin Vaccine Institute PDP. Innovations developed by Sabin Vaccine Development—funded by the Bill & Melinda Gates Foundation, the Dutch Ministry of Foreign Affairs and others—are sometimes referred to as “antipoverty vaccines” because of their impact on both global health and economic development. Antipoverty vaccines against hookworm are now in clinical trials in Brazil, while a new vaccine for schistosomiasis will soon undergo clinical testing. The vaccines for Chagas disease, leishmaniasis, and SARS are at an earlier stage of development, with support from the NIAID, NIH, Carlos Slim Health Institute, Southwest Electric Energy Medical Research Institute, and key individuals.
The Sabin Vaccine Institute PDP develops new antipoverty vaccines jointly with innovative developing countries, such as Brazil and Mexico, with aspirations to extend these activities to the Middle East and Asia. Hotez writes extensively about vaccine diplomacy, i.e., the opportunity of using vaccines as instruments of foreign policy and to promote global peace, especially among poor countries seeking nuclear weapons technology.
Neglected Tropical Disease Policy and Advocacy
In addition to his R&D activities, Prof. Hotez is a leading global health advocate and policymaker in the area of neglected tropical diseases, with an emphasis on providing impoverished populations access to essential and existing medicines for neglected tropical diseases. His 2005-06 papers in the Public Library of Science (PLOS) co-authored with thought leaders from the UK and WHO helped to consolidate the concept of the ‘NTDs’ and led to the implementation of “rapid impact packages” of essential medicines for the NTDs now reaching hundreds of millions of people in low income countries through support from the US Agency for International Development (USAID) and other sources. These activities helped to promote the establishment of the Global Network for NTDs, which Hotez co-founded in 2006 Global Network for Neglected Tropical Diseases (“Global Network”) with leading experts in the field. The Global Network, launched at the Clinton Global Initiative and funded by the Bill & Melinda Gates Foundation, highlights the horrific health and educational effects of neglected tropical diseases and advocates for their control and elimination. As a result of these activities, and the effort of public-private partnerships and NGOs, today more than 250 million people are receiving essential medicines for neglected tropical diseases.
Hotez is also the founding Editor-In-Chief of the Public Library of Science (PLoS) Neglected Tropical Diseases, the first online open access medical journal focused exclusively on neglected tropical diseases.
His papers in PLOS NTDs on the Geopolitics of NTDs provide a new framework for incorporating NTDs into U.S. foreign policy and helped to launch the concept known as ‘vaccine diplomacy’. More recently, Prof. Hotez is expanding his efforts to take on NTDs among the poor living in the U.S. and other developed countries. His 2008 PLOS NTDs paper on “Neglected infections in the United States of America” highlighted the hidden burden of NTDs in the American South while his 2012 op-ed piece in the New York Times, "Tropical Diseases: The New Plague of Poverty", emphasized the especially high burden of NTDs among the poor in Texas. His work is leading to a new global health framework based on extreme poverty regardless of whether it occurs in low- and middle-income countries or industrialized nations. Many of these concepts are articulated in his book “Forgotten People, Forgotten Diseases” ASM Press.
Blue Marble Health
In January 2013 during a speech at the James Baker Institute for Public Policy at Rice University in Houston, Texas, Professor Peter Hotez introduced the concept of “Blue Marble Health” to raise awareness on neglected tropical diseases and their disproportionate impact on the extreme poor living among the wealthiest G20 (Group of 20) countries, including 4 – 5 million Americans in the United States living on less than $2 a day. In subsequent policy papers published in Foreign Policy and PLOS NTDs, Dr. Hotez provided evidence that with some important exceptions most of the world’s NTDs paradoxically affect populations living in G20 countries, especially in areas of concentrated poverty such as northern India, southern Mexico, western China, northeastern Brazil, and even the southern United States (see map). This finding is in contrast to traditional global health views of developed vs. developing countries. Blue Marble Health has also emerged as a key concept for science and vaccine diplomacy, particularly with respect to exercising diplomatic pressure on the G20 countries to take greater responsibility for their impoverished populations and for people living in poverty everywhere.
National School of Tropical Medicine at Baylor College of Medicine
Hotez' work among people with NTDs in Texas helped to lead to the establishment of the National School of Tropical Medicine (NSTM) at Baylor College of Medicine (BCM). It is the first school in the United States solely committed to addressing the world's most pressing tropical disease issues.
The vision of the NSTM is to harness the scientific horsepower of the Texas Medical Center and apply it toward solving global health problems affecting the world's poorest people. The NSTM believes that all lives have equal value, and there is an urgent need to address diseases that disproportionately affect the world’s poorest people – otherwise forgotten people with forgotten diseases.
The National School of Tropical Medicine provides training programs to allow a new cadre of health professionals to conduct innovative fundamental, translational and clinical research in the field of tropical medicine. The NSTM also offers clinical training for tropical diseases, providing the opportunity for students and health professionals to gain valuable hands-on experience to complement their research interests, course of study or profession.
In addition, programs to address the global health policy and advocacy of Neglected Tropical Diseases (NTDs). These are infectious and parasitic diseases that initiate and perpetuate poverty and suffering, worldwide. Signature programs develop the establishment of diplomas, certificates, workshops and graduate degrees in tropical medicine. NSTM will also launch a variety of basic and biotechnology educational programs to train a new generation of scientists and health professionals.
Biography and Education
Hotez was born in Hartford, Connecticut. He received a BA in Molecular Biophysics and Biochemistry magna cum laude (Phi Beta Kappa) from Yale University in 1980, a PhD from Rockefeller University in 1986, and a Doctorate in Medicine from Weill Cornell Medical College in 1987. His doctoral dissertation and postdoctoral training were in the area of hookworm molecular pathogenesis and vaccine development.
He obtained pediatric residency training at the Massachusetts General Hospital, and postdoctoral training in clinical pediatric infectious diseases and molecular parasitology at Yale University School of Medicine. Prior to becoming founding Dean of the National School of Tropical Medicine, Dr. Hotez was Professor and Chair of the Department of Microbiology, Immunology, and Tropical Medicine at George Washington University previously and prior to that associate professor at Yale University School of Medicine.
Awards and Memberships
Hotez has received several awards throughout his career, including:
- 2011 - The Abraham Horwitz Award from the Pan American Health and Education Foundation and Pan American Health Organization for excellence in leadership in Inter-American public health guidelines
- 2006 - The Leverhulme Medal from the Liverpool School of Tropical Medicine.
- 2003 - The Bailey K. Ashford Medal from the American Society of Tropical Medicine and Hygiene for distinguished work in tropical medicine.
- 1999 - The Ward Medal from the American Society of Parasitologists for outstanding contributions to the field of parasitology.
In 2008, he was elected to membership in the Institute of Medicine of the National Academies. He is an ambassador of the Paul G. Rogers Society for Global Health Research, a Fellow of the American Academy of Pediatrics (FAAP), a member of the World Health Organization Scientific and Technical Advisory Committee for WHO TDR (Special Programme on Tropical Diseases Research), and in 2011, Hotez was appointed as a member of the National Institutes of Health (NIH) Council of Councils. He is a member of the inaugural class of Fellows of the American Society of Tropical Medicine and Hygiene.
Publications and Media
Hotez is the author of more than 330 scientific and technical papers on NTDs. In addition he is the author of Forgotten People, Forgotten Diseases: The Neglected Tropical Diseases and Their Impact on Global Health and Development, co-author of Parasitic Diseases, 5th Edition, a co-editor of Krugman's Infectious Diseases of Children, 11th Edition, and co-editor of Manson's Tropical Diseases, 23rd Edition and Feigin and Cherry's Textbook of Pediatric Infectious Diseases, 7th Edition. In addition, Hotez writes frequently for lay audiences, including papers in Scientific American and op-ed pieces in the New York Times, Los Angeles Times, and Huffington Post. He has been interviewed on numerous national TV and news programs, such as CNN, NPR, Charlie Rose and PRI. He has also consulted for popular television shows that highlight tropical diseases, including House and Private Practice.
Selected scientific publications:
- Hotez PJ, Brooker S, Bethony JM, Bottazzi ME, Loukas A, Xiao S. Hookworm infection. NEW ENGLAND JOURNAL OF MEDICINE, 2004; 351: 799-807.
- Hotez PJ, Molyneux DH, Fenwick A, Kumaresan J, Sachs SE, Sachs JD, Savioli L. Control of neglected tropical diseases. NEW ENGLAND JOURNAL OF MEDICINE, 2007; 357: 1018-27.
- Hotez PJ. Neglected infections of poverty in the United States of America. PLOS NEGLECTED TROPICAL DISEASES, 2008; 2: e256.
- Hotez PJ, Fenwick A, Savioli L, Molyneux DH. Rescuing the “bottom billion” through neglected tropical disease control. THE LANCET, 2009; 373: 1570-4.
- Hotez PJ. A plan to defeat neglected tropical diseases. SCIENTIFIC AMERICAN, 2010; 302: 90-6.
- Hotez PJ. America's most distressed areas and their neglected infections: the United States Gulf Coast and the District of Columbia. PLOS NEGLECTED TROPICAL DISEASES, 2011; 5: e843.
- Hotez PJ, Neeraj M, Rubinstein J, Sachs DJ. Integrating neglected tropical diseases into HIV/AIDS, tuberculosis, and malaria control. NEW ENGLAND JOURNAL OF MEDICINE, 2011; 364: 2086-9.
- Pearson MS, Pickering DA, Tribolet L, McSorley HJ, Bethony JM, Dougall AM, Hotez PJ, Loukas A. Enhanced protective efficacy of chimeric forms of the schistosomiasis vaccine antigen Sm-TSP-2. PLOS NEGLECTED TROPICAL DISEASES, 2012; 6: 1564.
- Hotez PJ, Bottazzi ME, Dumonteil E, Kamhawi E, Valenzuela J, Ortega J, Ponce de Leon Rosales S, Betancourt Cravioto M, Tapia-Conyer R. Texas and Mexico: Sharing a Legacy of Poverty and Neglected Tropical Diseases. PLOS NEGLECTED TROPICAL DISEASES, 2012; 6: e1497.
- Hotez PJ, Dumonteil E, Woc-Colburn L, Serpa-Alvarez JA, Bezek S, Edwards MS, Hallmark CJ, Musselwhite LW, Flink BJ, Bottazzi ME. Chagas disease: the new HIV/AIDS of the Americas. PLOS NEGLECTED TROPICAL DISEASES, 2012; 6: e1498.
- Hotez PJ. American Society of Tropical Medicine and Hygiene Presidential Address. The four horsemen of the apocalypse: tropical medicine in the fight against plague, death, famine, and war. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2012; 87: 3-10.
- Goud GN, Deumic V, Gupta R, Brelsford J, Zhan B, Gillespie P, Rezende W, Plieskatt JI, Hotez PJ, Bottazzi ME. Expression, purification, and molecular analysis of the Necator americanus glutathione S-transferase (Na-GST-1): a production process developed for a lead candidate recombinant hookworm vaccine antigen. PROTEIN EXPRESSION AND PURIFICATION, 2012; 83: 145-51.
- Barry MA, Bezek S, Serpa-Alvarez J, Hotez PJ, Woc-Colburn L. Neglected infections of poverty in Texas and the United States: management and treatment options. CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2012; 92: 170-81.
- Dumonteil E, Bottazzi ME, Zhan B, Heffernan MJ, Jones K, Valenzuela J, Kamhawi S, Ortega J, Ponce de Leon Rosales S, Lee BY, Bacon KM, Fleischer B, Slingsby BT, Betancourt Cravioto M, Tapia-Conyer R, Hotez PJ. Accelerating the development of a therapeutic vaccine for human Chagas disease: Rationale and prospects. EXPERT REVIEW OF VACCINES, 2012; 11: 1043-55.
- Andrus J, Bottazzi ME, Chow J, Goraleski KA, Fisher-Hoch S, Lambuth JK, Lee BY, Margolis H, McCormick J, Melby P, Murray KO, Rico-Hesse R, Valenzuela JG, Hotez PJ. Ears of the armadillo: global health research and neglected diseases in Texas. PLOS NEGLECTED TROPICAL DISEASES 2013; 7: e2021.
- Curti E, Kwityn C, Zhan B, Gillespie P, Brelsford J, Deumic V, Plieskatt J, Rezende WC, Tsao E, Kampanayil B, Hotez PJ, Bottazzi ME. Expression at a 20L scale and purification of the extracellular domain of the Schistosoma mansoni TSP-2 recombinant protein: A vaccine candidate for human intestinal schistosomiasis. HUMAN VACCINES AND IMMUNOTHERAPEUTICS 2013; 9: 2342-2350.
- Cheng BW, Curti E, Rezende WC, Kwityn C, Zhan B, Gillespie P; Plieskatt J, Joshi SB, Volkin DB, Hotez PJ, Middaugh CR, Bottazzi ME. Biophysical and formulation studies of the Schistosoma mansoni TSP-2 extracellular domain recombinant protein, a lead vaccine candidate antigen for intestinal schistosomiasis. HUMAN VACCINES AND IMMUNOTHERAPEUTICS 2013; 9: 2351-60.
- Hotez PJ, Singh S, Zhou XN. Advancing Sino-Indian cooperation to combat tropical diseases. PLOS NEGLECTED TROPICAL DISEASES 7: e2204.
- Barry MA, Weatherhead JE, Hotez PJ, Woc-Colburn L. Childhood Parasitic Infections Endemic to the United States. PEDIATRIC CLINICS OF NORTH AMERICA 2013; 60: 471-85.
- Hotez PJ, Dumonteil E, Betancourt Cravioto M, Bottazzi ME, Tapia Conyer R, Meymandi S, Karunakara U, Ribeiro I, Cohen RM, Pecoul B. An unfolding tragedy of Chagas disease in North America]. PLOS NEGLECTED TROPICAL DISEASES 7:e2300.
- Hotez PJ. NTDs V.2.0: “Blue Marble Health”—Neglected Tropical Disease Control and Elimination in a Shifting Health Policy Landscape. PLOS NEGLECTED TROPICAL DISEASES 7: e2570.
- Hotez PJ. In India’s forgotten diseases, an opportunity. THE HINDU, March 8, 2011.
- Hotez PJ. School takes on ancient scourges. HOUSTON CHRONICLE, August 21, 2011.
- Hotez P. A new tropical medicine clinic for ‘third world America’. HUFFINGTON POST, October 27, 2011.
- Hotez P. Engaging Iran through vaccine diplomacy. MILLER-McCUNE, November 30, 2011.
- Hotez P, Kazura J. A military cutback we can’t afford: fighting tropical diseases. THE ATLANTIC, January 19, 2012.
- Hotez P. The London Declaration: a tipping point for the world’s poor. HUFFINGTON POST, January 30, 2012.
- Hotez P. Saving 7 million pregnancies in Africa. HUFFINGTON POST, March 19, 2012.
- Hotez PJ. Tropical diseases: the new plague of poverty. THE NEW YORK TIMES, August 19, 2012.
- Hotez PJ. Campaign spending: what else can $2 billion buy? HUFFINGTON POST, November 13, 2102.
- Hotez PJ. Combating diseases of poverty requires joint US-Middle East effort. GLOBALPOST, November 19, 2012.
- Hotez PJ. A reunification Rx for Korea. LOS ANGELES TIMES, January 24, 2013.
- Hotez PJ. The disease next door. FOREIGN POLICY, March 25, 2013.
- Hotez PJ. Arab revolutions: Ignoring a potential catastrophe. ALJAZEERA AMERICA, August 16, 2013.
- Hotez PJ. Next Steps in US-Iran Diplomacy: Vaccines. PACIFIC STANDARD, November 6, 2013.
Hotez has a lifelong passion and interest in tropical diseases, which he said began when he first read the book Microbe Hunters as a child. He currently lives in the Montrose area of Houston, Texas with his wife Ann and two of his four children (Rachel and Daniel). His eldest son Matthew is a musician in Washington DC and his eldest daughter Emily is working towards a PhD in developmental psychology at City University of New York.
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