Born in Kutaisi, Otskheli studied at the Kutaisi realschule and the Tbilisi Academy of Fine Arts in the 1920s. Through most of his career Otskheli had a creative relationship with the director Kote Marjanishvili who invited the young artist to his theatre in Kutaisi in 1928. Otskheli’s visual experiments and skillful use of stage for massive designs with a series of subtle elements earned him recognition, but he soon came under pressure from Stalin’s lieutenant in the Caucasus, Lavrentiy Beria. In 1936, Otskheli fled Beria’s persecution to Moscow where he was recruited by his fellow countryman Sergo Amaghlobeli, then the director of Moscow Maly Theatre. In 1937, both Otskheli and Amaghlobeli were arrested and shot on trumped-up charges of treason.