Phellinus linteus

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Phellinus linteus
Scientific classification
Kingdom: Fungi
Phylum: Basidiomycota
Class: Basidiomycetes
Order: Hymenochaetales
Family: Hymenochaetaceae
Genus: Phellinus
Species: P. linteus
Binomial name
Phellinus linteus

Phellinus linteus (Japanese "meshimakobu", Chinese "song gen", Korean "sanghwang", English "Meshima", American English "black hoof mushroom") is a medicinal mushroom used in Japan, Korea and China for centuries to prevent ailments as diverse as gastroenteric dysfunction, diarrhea, haemorrhage and cancers.

It is shaped like a hoof, has a bitter taste, and in the wild grows on mulberry trees. The stem's color ranges from dark brown to black. In Korean traditional medicine, the mushroom is consumed in the form of hot tea.

Early research has suggested that Phellinus linteus has anti-breast cancer activity.[1][2]

A paper published by Harvard Medical School reported that Phellinus linteus is a promising anti-cancer agent, but that more research is required to understand the mechanisms behind its anti-cancer activity.[3]

Nine compounds were isolated from the active ethylacetate fraction of the fruiting body and identified as protocatechuic acid, protocatechualdehyde, caffeic acid, ellagic acid, hispidin, davallialactone, hypholomine B, interfungins A and inoscavin A of which interfungins A is a potent inhibitor of protein glycation.[4]

Extracts from fruit-bodies or mycelium of Phellinus linteus stimulate the hormonal and cell-mediated immune function; quench the inflammatory reactions caused by a variety of stimuli, and suppress tumor growth and metastasis.[5]

References[edit]

  1. ^ Lu TL, Huang GJ, Lu TJ, et al. (August 2009). "Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells". Food and Chemical Toxicology 47 (8): 2013–21. doi:10.1016/j.fct.2009.05.023. PMID 19477214. 
  2. ^ Sliva D, Jedinak A, Kawasaki J, Harvey K, Slivova V (April 2008). "Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling". British Journal of Cancer 98 (8): 1348–56. doi:10.1038/sj.bjc.6604319. PMC 2361714. PMID 18362935. 
  3. ^ Zhu T, Kim SH, Chen CY (2008). "A medicinal mushroom: Phellinus linteus". Current Medicinal Chemistry 15 (13): 1330–5. doi:10.2174/092986708784534929. PMID 18537612. 
  4. ^ Lee YS, Kang YH, Jung JY, et al. (October 2008). "Protein glycation inhibitors from the fruiting body of Phellinus linteus" ([dead link]). Biological & Pharmaceutical Bulletin 31 (10): 1968–72. doi:10.1248/bpb.31.1968. PMID 18827365. 
  5. ^ Zhu, Tongbo; Sung-Hoon Kim; Chang-Yan Chen."A Medicinal Mushroom: Phellinus Linteus". Current Medicinal Chemistry, 2008, Vol. 15 Issue 13, p1330-1335, 6p,

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