|This article's factual accuracy is disputed. (March 2011)|
Phenomics is an area of biology concerned with the measurement of phenomes — the physical and biochemical traits of organisms — as they change in response to genetic mutation and environmental influences. It is used in functional genomics, pharmaceutical research, metabolic engineering and increasingly in phylogenetics.
An important field of research today is trying to improve, both qualitatively and quantitatively, the capacity to measure phenomes. This include developing high-throughput measurement systems. For example, the Australian Plant Phenomics Facility, an initiative of the Australian government, has developed a number of new instruments for comprehensive and fast measurements of phenotypes in both the lab and the field.
Highly cited publications concerning phenomics include:
- Schilling, C.H.; Edwards, J.S.; Palsson, B.O. (1999), "Toward metabolic phenomics: analysis of genomic data using flux balances", Biotechnology Progress 15 (3): 288–295, doi:10.1021/bp9900357, PMID 10356245
- Gerlai, R. (2002), "Phenomics: fiction or the future?", Trends in Neurosciences 25 (10): 506–509, doi:10.1016/S0166-2236(02)02250-6, PMID 12220878
- Freimer, N.; Sabatti, C. (2003), "The human phenome project", Nature Genetics (Nature Publishing Group) 34 (1): 15–21, doi:10.1038/ng0503-15, PMID 12721547
- Warringer, J.; Ericson, E.; Fernandez, L.; Nerman, O.; Blomberg, A. (2003), "High-resolution yeast phenomics resolves different physiological features in the saline response", Proceedings of the National Academy of Sciences of the United States of America 100 (26): 15724–15729, doi:10.1073/pnas.2435976100, PMC 307635, PMID 14676322
- Zbuk, K.M.; Eng, C. (2006), "Cancer phenomics: RET and PTEN as illustrative models", Nature Reviews Cancer 7 (1): 35–45, doi:10.1038/nrc2037, PMID 17167516
- Eberius, M.; Lima-Guerra, J. (2009), "High-Throughput Plant Phenotyping – Data Acquisition, Transformation, and Analysis", Bioinformatics 7 (1): 259–278, doi:10.1007/978-0-387-92738-1_13, ISBN 978-0-387-92737-4
- Houle, D.; Govindaraju, D.R.; Omholt, S. (2010), "Phenomics: the next challenge", Nature Reviews Genetics 11 (12): 855–66, doi:10.1038/nrg2897, PMID 21085204
- PhenomicDB, a database combining phenotypic and genetic data from several species
- Phenotype microarray
- O’Leary, M. A., J. I. Bloch, J. J. Flynn, T. J. Gaudin, A. Giallombardo, N. P. Giannini, S. L. Goldberg, B. P. Kraatz, Z.-X. Luo, J. Meng, X. Ni, M. J. Novacek, F. A. Perini, Z. Randall, G. W. Rougier, E. J. Sargis, M. T. Silcox, N. B. Simmons, M. Spaulding, P. M. Velazco, M. Weksler, J. R. Wible, and A. L. Cirranello. 2013. The placental mammal ancestor and the post-K-Pg radiation of placentals. Science. 332:662-667.
- According to a Google scholar search performed 2010-05-01.
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