Phenotypic switching
From Wikipedia, the free encyclopedia
Phenotypic switching (a.k.a. phenotypic dimorphism) is switching between two cell-types. An example is Candida albicans, which, when it infects host tissue, switches from the usual unicellular yeast-like form into an invasive, multicellular filamentous form.[1] This switching between two cell-types is known as dimorphism.
Phenotypic switching in C. albicans include the switch from white cells to opaque cells in need for sexual mating.
[edit] References
- ^ Kumamoto CA, Vinces MD (2005). "Contributions of hyphae and hypha-co-regulated genes to Candida albicans virulence". Cell. Microbiol. 7 (11): 1546–54. doi:10.1111/j.1462-5822.2005.00616.x. PMID 16207242.
[edit] External links
- Neville SE, Baigent S, Lowry PJ (December 2001). "Are Hox genes responsible for the phenotypic switching and zonation of the adult adrenal cortex?". Endocrine Abstracts 2: 52. http://www.endocrine-abstracts.org/ea/0002/ea0002p52.htm.
- D'Souza CA, Heitman J (December 2001). "It infects me, it infects me not: phenotypic switching in the fungal pathogen Cryptococcus neoformans". J. Clin. Invest. 108 (11): 1577–8. doi:10.1172/JCI14497. PMC 200997. PMID 11733551. http://www.jci.org/cgi/content/full/108/11/1577.
- Sonneborn A, Tebarth B, Ernst JF (1 September 1999). "Control of white-opaque phenotypic switching in Candida albicans by the Efg1p morphogenetic regulator". Infect. Immun. 67 (9): 4655–60. PMC 96790. PMID 10456912. http://iai.asm.org/cgi/pmidlookup?view=long&pmid=10456912.
- Javan C, Shaunak S (January 22-26, 1997). "Repeated phenotypic switching of HIV-1 in AIDS patients sampled regularly over 2 years.". 4th Conference on Retroviruses and Opportunistic Infections. Washington, DC. http://www.aegis.com/conferences/croi/1997/450.html.
