Phenprobamate

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Phenprobamate
Phenprobamate.svg
Systematic (IUPAC) name
3-Phenylpropylcarbamate
Clinical data
AHFS/Drugs.com International Drug Names
Legal status ?
Pharmacokinetic data
Half-life 5 - 8 hours
Identifiers
CAS number 673-31-4 N
ATC code M03BA01
PubChem CID 4770
ChemSpider 4606 YesY
UNII UJZ473TPS0 YesY
KEGG D01824 YesY
ChEMBL CHEMBL1079576 YesY
Chemical data
Formula C10H13NO2 
Mol. mass 179.22
 N (what is this?)  (verify)

Phenprobamate (Gamaquil, Isotonil) is a centrally acting skeletal muscle relaxant, with additional sedative and anticonvulsant effects. Overdose is similar to barbiturates. Its mechanism of action is probably similar to meprobamate. Phenprobamate was previously used in humans as an anxiolytic, and is still sometimes used in general anesthesia and for treating muscle cramps and spasticity. Phenprobamate is still used in some European countries, but it has generally been replaced by newer drugs. Phenprobamate is metabolized by oxidative degradation of the carbamate group and ortho-hydroxylation of the benzene ring, and is eliminated in urine by the kidneys.

Doses range from 400 to 800 mg, up to 3 times a day.

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