Phensuximide

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Phensuximide
Phensuximide.svg
Systematic (IUPAC) name
1-methyl-3-phenyl-pyrrolidine-2,5-dione
Clinical data
MedlinePlus a682237
Legal status
?
Pharmacokinetic data
Protein binding 21%
Identifiers
CAS number 86-34-0
ATC code N03AD02
PubChem CID 6839
DrugBank DB00832
ChemSpider 6578 YesY
UNII 6WVL9C355G YesY
KEGG D00508 YesY
ChEMBL CHEMBL797 YesY
Chemical data
Formula C11H11NO2 
Mol. mass 189.211 g/mol
 YesY (what is this?)  (verify)

Phensuximide is an anticonvulsant in the succinimide class.

Chemistry[edit]

Phensuximide, 1-methyl-3-phenylpyrrolidine-2,5-dione is synthesized by the reaction of phenylsuccinic acid or its anhydride with methylamine. Phensuximide synthesis.png

  • C.A. Miller, L.M. Long, U.S. Patent 2,643,258 (1953).
  • Miller, C. A.; Long, L. M. (1951). "Anticonvulsants. I. An Investigation of N-R-α-R1-α-Phenylsuccinimides". Journal of the American Chemical Society 73 (10): 4895–8. doi:10.1021/ja01154a126.  edit

External links[edit]

  • DDB 31648
  • Rankin G, Cressey-Veneziano K, Wang R, Brown P (1986). "Urinary tract effects of phensuximide in the Sprague-Dawley and Fischer 344 rat.". J Appl Toxicol 6 (5): 349–56. doi:10.1002/jat.2550060509. PMID 3772011.