Phenylethanolamine N-methyltransferase

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phenylethanolamine N-methyltransferase
Symbol PNMT
Alt. symbols PENT
Entrez 5409
HUGO 9160
OMIM 171190
RefSeq NM_002686
UniProt P11086
Other data
EC number
Locus Chr. 17 q21-q22

Phenylethanolamine N-methyltransferase (PNMT) is an enzyme found in the adrenal medulla that converts norepinephrine (noradrenaline) to epinephrine (adrenaline).

PNMT is positively influenced by cortisol, which is produced in the adrenal cortex.

S-adenosyl-L-methionine (SAM) is a required cofactor.[1] PNMT catalyzes the transfer of a methyl group from SAM to norepinephrine, converting it into epinephrine. This enzyme also converts phenethylamine to N-methylphenethylamine, an isomer of amphetamine.[2][3]

Human biosynthesis pathway for trace amines and catecholamines[6]

PNMT plays an important role in trace amine and catecholamine biosynthesis.


  1. ^ Wong DL, Lesage A, Siddall B, Funder JW (November 1992). "Glucocorticoid regulation of phenylethanolamine N-methyltransferase in vivo". The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 6 (14): 3310–5. PMID 1426768. 
  2. ^ Pendleton, RG; Gessner, G; Sawyer, J (September 1980). "Studies on lung N-methyltransferases, a pharmacological approach.". Naunyn-Schmiedeberg's archives of pharmacology 313 (3): 263–8. doi:10.1007/BF00505743. PMID 7432557. 
  3. ^ Broadley, KJ (March 2010). "The vascular effects of trace amines and amphetamines.". Pharmacology & therapeutics 125 (3): 363–75. doi:10.1016/j.pharmthera.2009.11.005. PMID 19948186. 
  4. ^ Broadley KJ (March 2010). "The vascular effects of trace amines and amphetamines". Pharmacol. Ther. 125 (3): 363–375. doi:10.1016/j.pharmthera.2009.11.005. PMID 19948186. 
  5. ^ Lindemann L, Hoener MC (May 2005). "A renaissance in trace amines inspired by a novel GPCR family". Trends Pharmacol. Sci. 26 (5): 274–281. doi:10.1016/ PMID 15860375. 
  6. ^ [4][5]

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