Phenylethanolamine N-methyltransferase
From Wikipedia, the free encyclopedia
| phenylethanolamine N-methyltransferase | |
|---|---|
| Identifiers | |
| Symbol | PNMT |
| Alt. symbols | PENT |
| Entrez | 5409 |
| HUGO | 9160 |
| OMIM | 171190 |
| RefSeq | NM_002686 |
| UniProt | P11086 |
| Other data | |
| EC number | 2.1.1.28 |
| Locus | Chr. 17 q21-q22 |
Phenylethanolamine N-methyltransferase (PNMT) is an enzyme found in the adrenal medulla that converts norepinephrine (noradrenaline) to epinephrine (adrenaline).
PNMT is positively influenced by cortisol, which is produced in the adrenal cortex.
S-adenosyl-L-methionine (SAM) is a required cofactor.[1] PNMT catalyzes the transfer of a methyl group from SAM to norepinephrine, converting it into epinephrine.
References [edit]
- ^ Wong DL, Lesage A, Siddall B, Funder JW (November 1992). "Glucocorticoid regulation of phenylethanolamine N-methyltransferase in vivo". The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 6 (14): 3310–5. PMID 1426768.
External links [edit]
- Phenylethanolamine N-Methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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