|Molar mass||152.22 g·mol−1|
|Appearance||White to slightly yellow powder|
|Melting point||145 to 150 °C (293 to 302 °F; 418 to 423 K)|
|Soluble in boiling water|
LD50 (Median lethal dose)
|3 mg/kg (oral, rat)|
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
|what is: / ?)(|
About 70% of people can taste PTC, varying from a low of 58% for indigenous peoples of Australia and New Guinea to 98% for indigenous peoples of the Americas.[dead link] One study has found that non-smokers and those not habituated to coffee or tea have a statistically higher percentage of tasting PTC than the general population. PTC does not occur in food, but related chemicals do, and food choice is related to a person's ability to taste PTC.
The genetic taste phenomenon of PTC was discovered in 1931 when a DuPont chemist named Arthur Fox accidentally released a cloud of a fine crystalline PTC. A nearby colleague complained about the bitter taste, while Fox, who was closer and should have received a strong dose, tasted nothing. Fox then continued to test the taste buds of assorted family and friends, setting the groundwork for future genetic studies. The genetic correlation was so strong that it was used in paternity tests before the advent of DNA matching.
In 1976, a remarkable inverse relationship between taster status for PTC and for a bitter component of the fruit of the tree Antidesma bunius was discovered. Research on the implications still continues.
Some chimpanzees share the ability to taste PTC. However, chimpanzee PTC tasting relies on a different taste receptor than human tasting, suggesting that the ability evolved independently in both species.
Role in taste
There is a large body of evidence linking the ability to taste thiourea compounds and dietary habits. Much of this work has focused on 6-propyl-2-thiouracil (PROP), a compound related to PTC that has lower toxicity. A supertaster has more of an ability to taste PTC. On the other hand, heavy cigarette smokers are more likely to have high PTC and PROP thresholds (i.e. are relatively insensitive).
Ability to taste PTC may be correlated with a dislike of plants in the Brassica genus, presumably due to chemical similarities.
There are three SNPs (single nucleotide polymorphisms) along the gene that may render its proteins unresponsive. There is conflicting evidence as to whether the inheritance of this trait is dominant or incomplete dominant. Any person with a single functional copy of this gene can make the protein and is sensitive to PTC. Some studies have shown that homozygous tasters experience a more intense bitterness than people that are heterozygous; other studies have indicated that another gene may determine taste sensitivity.
Chimpanzees and orangutans also vary in their ability to taste PTC, with the proportions of tasters and non-tasters similar to that in humans.
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