Philippa Marrack

Philippa "Pippa" Marrack
Philippa "Pippa" Marrack
Institutions	National Jewish Health
Alma mater	Cambridge University; University of California, San Diego
Doctoral advisor	Alan Munro
Known for	T cells, autoimmune disease
Notable awards	Louisa Gross Horwitz Prize (1995)
Spouse	John W. Kappler

Philippa "Pippa" Marrack FRS is an English biologist, based in the United States, best known for her research into T cell development, T cell apoptosis and survival, adjuvants, autoimmune disease, and for identifying superantigens, the mechanism behind toxic shock syndrome.^[1] She collaborates with her husband, John W. Kappler.

Biography [edit]

Marrack was born in England, and completed both undergraduate and Ph.D. work at New Hall, Cambridge University. To earn her Ph.D, she worked at the MRC Laboratory of Molecular Biology with Alan Munro, where she began to work on T cells. She later did postdoctoral work with Richard Dutton at the University of California, San Diego.

Her first faculty position was with the University of Rochester, followed by National Jewish Health, Denver, Colorado and the University of Colorado.

J.W. Kappler, M. Roehm, P. Marrack, "T cell tolerance by clonal elimination in the thymus," Cell, v.49, n.2, pp. 273–80 (1987)
P. Marrack and J. Kappler, "The Staphylococcal Enterotoxins and Their Relatives," Science, v.248 (4956), pp. 705–11 (1990).
J.W. Kappler, U. Staerz, J. White, P.C. Marrack, "Self-Tolerance Eliminates T Cells Specific for MIS-Modified Products of the Major Histocompatibility Complex," Nature, 332 (6159): pp. 35–40 (1988).
J. White, et al. (P.C. Marrack), "The V(beta)-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletions in neonatal mice," Cell, v.56, n.1, pp. 27–35 (1989).

1986 - Appointed Investigator, Howard Hughes Medical Institute
1987 - Fellow (elected), Royal Society
1989 - Elected member, National Academy of Sciences
1990 - Royal Society Wellcome Foundation Prize
1993 - Cancer Research Institute William B. Coley Award
1993 - Paul Ehrlich and Ludwig Darmstaedter Prize
1994/95 - Louisa Gross Horwitz Prize (Columbia University)
2003 - Lifetime Achievement Award, American Association of Immunologists^[2]^[3]
2004 - L'Oreal UNESCO Women in Science Award
2005 - Pearl Meister Greengard Prize^[4]
Rabbi Shai Shackner Prize (University of Jerusalem)

Persondata
Name	Marrack, Philippa
Alternative names	Marrack, Pippa
Short description	United States-based English biologist and immunologist
Date of birth
Place of birth	United Kingdom
Date of death
Place of death