Phosducin

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Phosducin
Protein PDC PDB 2trc.png
PDB rendering based on 2trc.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PDC ; MEKA; PHD; PhLOP; PhLP
External IDs OMIM171490 MGI98090 HomoloGene1950 GeneCards: PDC Gene
RNA expression pattern
PBB GE PDC 211496 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5132 20028
Ensembl ENSG00000116703 ENSMUSG00000006007
UniProt P20941 Q9QW08
RefSeq (mRNA) NM_002597 NM_001159730
RefSeq (protein) NP_002588 NP_001153202
Location (UCSC) Chr 1:
186.41 – 186.43 Mb
Chr 1:
150.32 – 150.33 Mb
PubMed search [1] [2]

Phosducin, also known as PDC, is a human protein and gene.[1] It belongs to phosducin family of proteins.

This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. By associating with these subunits only, the Transducin alpha subunit will remain active for longer. This will increase the amount of time of visual excitation.

This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]

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