Phosphatidic acid phosphatase 2c

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Phosphatidic acid phosphatase type 2C
Symbols PPAP2C ; LPP2; PAP-2c; PAP2-g
External IDs OMIM607126 MGI1354945 HomoloGene2752 IUPHAR: 1440 GeneCards: PPAP2C Gene
EC number
RNA expression pattern
PBB GE PPAP2C 209529 at tn.png
More reference expression data
Species Human Mouse
Entrez 8612 50784
Ensembl ENSG00000141934 ENSMUSG00000052151
UniProt O43688 Q9DAX2
RefSeq (mRNA) NM_003712 NM_015817
RefSeq (protein) NP_003703 NP_056632
Location (UCSC) Chr 19:
0.28 – 0.29 Mb
Chr 10:
79.53 – 79.53 Mb
PubMed search [1] [2]

Lipid phosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the PPAP2C gene.[1][2][3]

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]


  1. ^ Leung DW, Tompkins CK, White T (May 1998). "Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells". DNA Cell Biol 17 (4): 377–85. doi:10.1089/dna.1998.17.377. PMID 9570154. 
  2. ^ Hooks SB, Ragan SP, Lynch KR (Jun 1998). "Identification of a novel human phosphatidic acid phosphatase type 2 isoform". FEBS Lett 427 (2): 188–92. doi:10.1016/S0014-5793(98)00421-9. PMID 9607309. 
  3. ^ a b "Entrez Gene: PPAP2C phosphatidic acid phosphatase type 2C". 

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