Phospholipid transfer protein

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Phospholipid transfer protein
Identifiers
Symbols PLTP ; BPIFE; HDLCQ9
External IDs OMIM172425 MGI103151 HomoloGene4536 ChEMBL: 5962 GeneCards: PLTP Gene
RNA expression pattern
PBB GE PLTP 202075 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5360 18830
Ensembl ENSG00000100979 ENSMUSG00000017754
UniProt P55058 P55065
RefSeq (mRNA) NM_001242920 NM_011125
RefSeq (protein) NP_001229849 NP_035255
Location (UCSC) Chr 20:
44.53 – 44.54 Mb
Chr 2:
164.84 – 164.86 Mb
PubMed search [1] [2]

Phospholipid transfer protein is a protein that in humans is encoded by the PLTP gene.

Function[edit]

The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene.[1]

Interactions[edit]

PLTP has been shown to interact with Apolipoprotein A1[2] and APOA2.[2]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Statin Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". 

References[edit]

  1. ^ "Entrez Gene: PLTP phospholipid transfer protein". 
  2. ^ a b Pussinen, P J; Jauhiainen M; Metso J; Pyle L E; Marcel Y L; Fidge N H; Ehnholm C (Jan 1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". J. Lipid Res. (UNITED STATES) 39 (1): 152–61. ISSN 0022-2275. PMID 9469594. 

Further reading[edit]

  • Jiang XC (2002). "The effect of phospholipid transfer protein on lipoprotein metabolism and atherosclerosis.". Front. Biosci. 7: d1634–41. doi:10.2741/jiang1. PMID 12086920. 
  • Albers JJ, Cheung MC (2005). "Emerging roles for phospholipid transfer protein in lipid and lipoprotein metabolism.". Curr. Opin. Lipidol. 15 (3): 255–60. doi:10.1097/00041433-200406000-00004. PMID 15166780. 
  • Dallinga-Thie GM, Dullaart RP, van Tol A (2007). "Concerted actions of cholesteryl ester transfer protein and phospholipid transfer protein in type 2 diabetes: effects of apolipoproteins.". Curr. Opin. Lipidol. 18 (3): 251–7. doi:10.1097/MOL.0b013e3280e12685. PMID 17495597. 
  • Whitmore TE, Day JR, Albers JJ (1996). "Localization of the human phospholipid transfer protein gene to chromosome 20q12-q13.1.". Genomics 28 (3): 599–600. doi:10.1006/geno.1995.1198. PMID 7490104. 
  • Albers JJ, Wolfbauer G, Cheung MC, et al. (1995). "Functional expression of human and mouse plasma phospholipid transfer protein: effect of recombinant and plasma PLTP on HDL subspecies.". Biochim. Biophys. Acta 1258 (1): 27–34. doi:10.1016/0005-2760(95)00091-p. PMID 7654777. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Day JR, Albers JJ, Lofton-Day CE, et al. (1994). "Complete cDNA encoding human phospholipid transfer protein from human endothelial cells.". J. Biol. Chem. 269 (12): 9388–91. PMID 8132678. 
  • Tu AY, Wolfbauer G, Albers JJ (1996). "Functional characterization of the promoter region of the human phospholipid transfer protein gene.". Biochem. Biophys. Res. Commun. 217 (3): 705–11. doi:10.1006/bbrc.1995.2830. PMID 8554588. 
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Hailman E, Albers JJ, Wolfbauer G, et al. (1996). "Neutralization and transfer of lipopolysaccharide by phospholipid transfer protein.". J. Biol. Chem. 271 (21): 12172–8. doi:10.1074/jbc.271.21.12172. PMID 8647810. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Pussinen PJ, Jauhiainen M, Metso J, et al. (1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I.". J. Lipid Res. 39 (1): 152–61. PMID 9469594. 
  • Jiang XC, D'Armiento J, Mallampalli RK, et al. (1998). "Expression of plasma phospholipid transfer protein mRNA in normal and emphysematous lungs and regulation by hypoxia.". J. Biol. Chem. 273 (25): 15714–8. doi:10.1074/jbc.273.25.15714. PMID 9624168. 
  • Jauhiainen M, Huuskonen J, Baumann M, et al. (1999). "Phospholipid transfer protein (PLTP) causes proteolytic cleavage of apolipoprotein A-I.". J. Lipid Res. 40 (4): 654–64. PMID 10191289. 
  • Qu SJ, Fan HZ, Kilinc C, Pownall HJ (1999). "Role of cysteine residues in human plasma phospholipid transfer protein.". J. Protein Chem. 18 (2): 193–8. doi:10.1023/A:1020628006453. PMID 10333293. 
  • Lie J, de Crom R, Jauhiainen M, et al. (2002). "Evaluation of phospholipid transfer protein and cholesteryl ester transfer protein as contributors to the generation of pre beta-high-density lipoproteins.". Biochem. J. 360 (Pt 2): 379–85. doi:10.1042/0264-6021:3600379. PMC 1222238. PMID 11716766. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
  • Kärkkäinen M, Oka T, Olkkonen VM, et al. (2002). "Isolation and partial characterization of the inactive and active forms of human plasma phospholipid transfer protein (PLTP).". J. Biol. Chem. 277 (18): 15413–8. doi:10.1074/jbc.M112247200. PMID 11854286. 
  • Murdoch SJ, Wolfbauer G, Kennedy H, et al. (2002). "Differences in reactivity of antibodies to active versus inactive PLTP significantly impacts PLTP measurement.". J. Lipid Res. 43 (2): 281–9. PMID 11861670.