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Skeletal formula of
Space-filling model of the phosphopantetheine molecule as an anion (2- charge)
2226-71-3 N
ChemSpider 103123 YesY
DrugBank DB03912 YesY
Jmol-3D images Image
MeSH phosphopantetheine
PubChem 115254
Molar mass 358.349 g/mol
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Phosphopantetheine, also known as 4'-Phosphopantetheine, is an essential prosthetic group of acyl carrier protein (ACP) and peptidyl carrier proteins (PCP) and aryl carrier proteins (ArCP) derived from Coenzyme A.[1] It is also present in formyltetrahydrofolate dehydrogenase.[2]


Phosphopantetheine fulfills two demands.

  • First, the intermediates remain covalently linked to the synthases (or synthetases) in an energy-rich thiol ester linkage.
  • Second, the flexibility and length of phosphopantetheine chain (approximately 2 nm) allows the covalently tethered intermediates to have access to spatially distinct enzyme active sites.

See also[edit]


  1. ^ Elovson J, Vagelos PR (July 1968). "Acyl carrier protein. X. Acyl carrier protein synthetase". J. Biol. Chem. 243 (13): 3603–11. PMID 4872726. 
  2. ^ Strickland KC, Hoeferlin LA, Oleinik NV, Krupenko NI, Krupenko SA (January 2010). "Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase". J. Biol. Chem. 285 (3): 1627–33. doi:10.1074/jbc.M109.080556. PMC 2804320. PMID 19933275.