This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming). Other names in common use include enolase, 2-phosphoglycerate dehydratase, 14-3-2-protein, nervous-system specific enolase, phosphoenolpyruvate hydratase, 2-phosphoglycerate dehydratase, 2-phosphoglyceric dehydratase, 2-phosphoglycerate enolase, gamma-enolase, and 2-phospho-D-glycerate hydro-lyase. This enzyme participates in glycolysis/gluconeogenesis. At least one compound, Phosphonoacetohydroxamate is known to inhibit this enzyme. The human gene that makes this enzyme is ENO2.