Phosphorylase kinase, alpha 1

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Phosphorylase kinase, alpha 1 (muscle)
Identifiers
Symbols PHKA1 ; PHKA
External IDs OMIM311870 MGI97576 HomoloGene1981 ChEMBL: 2905 GeneCards: PHKA1 Gene
EC number 2.7.11.19
Orthologs
Species Human Mouse
Entrez 5255 18679
Ensembl ENSG00000067177 ENSMUSG00000034055
UniProt P46020 P18826
RefSeq (mRNA) NM_001122670 NM_008832
RefSeq (protein) NP_001116142 NP_032858
Location (UCSC) Chr HG1438_PATCH:
71.8 – 71.93 Mb
Chr X:
102.51 – 102.64 Mb
PubMed search [1] [2]

Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform is an enzyme that in humans is encoded by the PHKA1 gene.[1]

The PHKA1 gene encodes the alpha subunit of muscle phosphorylase kinase (EC 2.7.1.38), a key regulatory enzyme of glycogen metabolism. Phosphorylase kinase consists of 4 copies of an alpha-beta-gamma-delta tetramer. The alpha, beta (PHKB; MIM 172490), and gamma (PHKG1; MIM 172470 and PHKG2; MIM 172471) subunits have several isoforms; the delta subunit is calmodulin (CALM1; MIM 114180). PHKA2 (MIM 306000) encodes the alpha subunit of liver-specific phosphorylase kinase and is also located on the X chromosome.[supplied by OMIM][1]

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