Porfimer sodium
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| Clinical data | |
| AHFS/Drugs.com | Consumer Drug Information |
| Licence data | EMA:Link, US FDA:link |
| Pregnancy cat. | C (US) |
| Legal status | ℞-only (US) |
| Routes | Intravenous |
| Pharmacokinetic data | |
| Bioavailability | NA |
| Protein binding | ~90% |
| Half-life | 21.5 days (mean) |
| Excretion | Fecal |
| Identifiers | |
| CAS number | 97067-70-4  87806-31-3 |
| ATC code | L01XD01 |
| PubChem | CID 57166 |
| DrugBank | APRD00078 |
| ChemSpider | 10482283  |
| UNII | Y3834SIK5F |
| ChEMBL | CHEMBL1201707 |
| Chemical data | |
| Formula | C68H74N8O11 (for n=0) |
| Mol. mass | 1179.36 g/mol (for n=0) |
| SMILES | eMolecules & PubChem |
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Porfimer sodium, sold as Photofrin, is a photosensitizer used in photodynamic therapy and radiation therapy and for palliative treatment of obstructing endobronchial non-small cell lung carcinoma and obstructing esophageal cancer.
Porfimer is a mixture of oligomers formed by ether and ester linkages of up to eight porphyrin units.[1] In practice, a red light source emitting at 630 nm is used to excite the Porfimer oligomers.[2]
[edit] Approvals and indications
It was approved in Canada in 1993 for the treatment of bladder cancer[2]. It was approved in Japan in 1994 (for early stage lung cancer?)[2]. It was approved by the U.S. FDA in December 1995 esophageal cancer, and in 1998, it was approved for the treatment of early non-small cell lung cancer[2].
In August 2003 the FDA approved its use for Barrett's esophagus.[3]
[edit] References
- ^ http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020451s019lbl.pdf
- ^ a b c d http://journals.lww.com/jto/Fulltext/2006/06000/Photodynamic_Therapy__PDT__for_Lung_Cancers.18.aspx "Photodynamic Therapy (PDT) for Lung Cancers" 2006
- ^ "FDA Patient Safety News: Show #20, October 2003". October 2003. http://www.accessdata.fda.gov/psn/printer-full.cfm?id=24. Retrieved 2009-08-17.
[edit] External links
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