Piceatannol
From Wikipedia, the free encyclopedia
| Piceatannol | |
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5-[(E)-2-(3,'-dihydroxyphenyl)vinyl]benzene-1,3-diol |
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Other names
3',4',3,5-tetrahydroxy-trans-stilbene |
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| Identifiers | |
| CAS number | 10083-24-6 |
| PubChem | 667639 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C14H12O4 |
| Molar mass | 244.24 g/mol |
| Exact mass | 244.073559 u |
| Appearance | Light tan to yellow powder |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Piceatannol is a stilbenoid, a type of phenolic compound. It is a metabolite of resveratrol found in red wine.
Astringin is a piceatannol glucoside.
[edit] Health effects
LMP2A, a viral protein-tyrosine kinase implicated in leukemia, non-Hodgkin's lymphoma and other diseases associated with Epstein-Barr virus, were found to be blocked by picetannol in vitro.[1] Therefore there is research interest in piceatannol as an anti-cancer and anti-EBV drug.[2]
[edit] See also
[edit] References
- ^ Geahlen RL, McLaughlin JL (1989). "Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor". Biochem. Biophys. Res. Commun. 165 (1): 241–5. doi:10.1016/0006-291X(89)91060-7. PMID 2590224.
- ^ Swanson-Mungerson M, Ikeda M, Lev L, Longnecker R, Portis T (2003). "Identification of latent membrane protein 2A (LMP2A) specific targets for treatment and eradication of Epstein-Barr virus (EBV)-associated diseases". J. Antimicrob. Chemother. 52 (2): 152–4. doi:10.1093/jac/dkg306. PMID 12837743.
