Piecemeal necrosis generally refers to a necrosis that occurs in fragments.
When used in relation to the liver, piecemeal necrosis (also termed troxis necrosis, nibbling necrosis and interface necrosis) refers specifically to a loss and degeneration of (limiting plate) hepatocytes at the lobular-portal-interface, producing a moth-eaten irregular appearance. Piecemeal necrosis of the liver is associated with a lymphocytic infiltrate into the adjacent parenchyma, and with destruction of individual hepatocytes along the edges of the portal tract.
- Wang, M.; Morgan, T.; Lungo, W.; Wang, L.; Sze, G. Z.; French, S. W. (2001). ""Piecemeal" Necrosis: Renamed Troxis Necrosis". Experimental and Molecular Pathology 71 (2): 137–146. doi:10.1006/exmp.2001.2397. PMID 11599920.
- Pathbase > MPATH 597: cell and tissue damage process > MPATH 13: piecemeal necrosis Retrieved July 2, 2011
- Transplant Pathology at the University of Pittsburgh > Chronic hepatitis > Chapter 3 > PATHOLOGIC FEATURES Last Modified: Mar 12, 2010
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