22 November 1729|
Bedous, Béarn, France
|Died||20 June 1778
Near the mouth of the Arkansas River
Laclède was sponsored by the New Orleans merchant Gilbert Antoine Maxent in 1763 to construct a trading post near the confluence of the Mississippi and Missouri rivers. Laclede and Chouteau set out from New Orleans in August, arriving at the confluence in December. The confluence area was too marshy to build a town, so they selected a site 18 miles (29 km) downriver.
Laclède returned to St. Louis in April 1764 with a design for the town, where Chouteau was overseeing clearing of the land. He was followed soon after by his common-law wife, Marie Thérèse Bourgeois Chouteau (Madame Chouteau).
Laclède had four children with Madame Chouteau: Jean Pierre (1758), Marie Pelagie (1760), Marie Louise (1762), and Victoire (1764) Chouteau. Because divorce was prohibited by law of both the Roman Catholic Church and in France, these children were baptized as the children of Madame Chouteau's legal husband, René Auguste Chouteau (père). René Chouteau had returned to France, after having abused and abandoned Madame Chouteau. Laclede and his descendants were influential in the St. Louis and regional economy and politics for many years. Auguste and Jean-Pierre Chouteau were partners in fur trading, and had a monopoly for several years with the Osage Native Americans up the Missouri River.
The St. Louis downtown riverfront area is named Laclede's Landing in his honor. He is also the namesake of Laclede County, Missouri, Laclede, Missouri, the Pierre Laclede Honors College at the University of Missouri–St. Louis, and the Pierre Laclede Elementary School in St. Louis. Laclede is also recognized with a star on the St. Louis Walk of Fame. 
- St. Louis Walk of Fame. "St. Louis Walk of Fame Inductees". stlouiswalkoffame.org. Retrieved 25 April 2013.
- "Pierre Laclède", National Park Service biography[dead link]
- "Pierre Laclede", St. Louis Walk of Fame
- "Remains of St. Louis founder's home believed to have been located"