Pinin

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Pinin, desmosome associated protein
Identifiers
Symbols PNN ; DRS; DRSP; SDK3; memA
External IDs OMIM603154 MGI1100514 HomoloGene37656 GeneCards: PNN Gene
RNA expression pattern
PBB GE PNN 212037 at tn.png
PBB GE PNN 212036 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5411 18949
Ensembl ENSG00000100941 ENSMUSG00000020994
UniProt Q9H307 O35691
RefSeq (mRNA) NM_002687 NM_008891
RefSeq (protein) NP_002678 NP_032917
Location (UCSC) Chr 14:
39.64 – 39.65 Mb
Chr 12:
59.07 – 59.07 Mb
PubMed search [1] [2]

Pinin is a protein that in humans is encoded by the PNN gene.[1][2]


Interactions[edit]

Pinin has been shown to interact with Keratin 8,[3] Keratin 18,[3] Keratin 19,[3] CTBP1,[4] RNPS1,[5][6] PRPF4B,[7] SFRS4,[8] PPIG,[9] SRRM2[8] and SFRS18.[8]

References[edit]

  1. ^ Ouyang P, Sugrue SP (January 1997). "Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex". J Cell Biol 135 (4): 1027–42. doi:10.1083/jcb.135.4.1027. PMC 2133386. PMID 8922384. 
  2. ^ "Entrez Gene: PNN pinin, desmosome associated protein". 
  3. ^ a b c Shi, J; Sugrue S P (May 2000). "Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus". J. Biol. Chem. (UNITED STATES) 275 (20): 14910–5. doi:10.1074/jbc.275.20.14910. ISSN 0021-9258. PMID 10809736. 
  4. ^ Alpatov, Roman; Munguba Gustavo Costa; Caton Paul; Joo Jeong Hoon; Shi Yang; Shi Yujiang; Hunt Marguerite E; Sugrue Stephen P (December 2004). "Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene". Mol. Cell. Biol. (United States) 24 (23): 10223–35. doi:10.1128/MCB.24.23.10223-10235.2004. ISSN 0270-7306. PMC 529029. PMID 15542832. 
  5. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  6. ^ Li, Chin; Lin Ru-Inn; Lai Ming-Chih; Ouyang Pin; Tarn Woan-Yuh (October 2003). "Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1". Mol. Cell. Biol. (United States) 23 (20): 7363–76. doi:10.1128/MCB.23.20.7363-7376.2003. ISSN 0270-7306. PMC 230327. PMID 14517304. 
  7. ^ Dellaire, Graham; Makarov Evgeny M; Cowger Jeff J M; Longman Dasa; Sutherland Heidi G E; Lührmann Reinhard; Torchia Joseph; Bickmore Wendy A (July 2002). "Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes". Mol. Cell. Biol. (United States) 22 (14): 5141–56. doi:10.1128/MCB.22.14.5141-5156.2002. ISSN 0270-7306. PMC 139773. PMID 12077342. 
  8. ^ a b c Zimowska, Grazyna; Shi Jia; Munguba Gustavo; Jackson Moira R; Alpatov Roman; Simmons Matthew N; Shi Yujiang; Sugrue Stephen P (November 2003). "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells". Invest. Ophthalmol. Vis. Sci. (United States) 44 (11): 4715–23. doi:10.1167/iovs.03-0240. ISSN 0146-0404. PMID 14578391. 
  9. ^ Lin, Chun Lun; Leu Steve; Lu Ming Chu; Ouyang Pin (August 2004). "Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles". Biochem. Biophys. Res. Commun. (United States) 321 (3): 638–47. doi:10.1016/j.bbrc.2004.07.013. ISSN 0006-291X. PMID 15358154. 

Further reading[edit]