Piperonyl butoxide

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Piperonyl butoxide
IUPAC name	5-[2-(2-butoxyethoxy)ethoxymethyl] -6-propyl-1,3-benzodioxole
Identifiers
CAS number	[51-03-6]
SMILES	CCCCOCCOCCOCC1=CC2=C(C=C1CCC)OCO2
Properties
Molecular formula	C19H30O5
Molar mass	338.438 g/mol
Density	1.05 g/cm3
Boiling point	155 °C
Hazards
Flash point	171 °C
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references

Piperonyl butoxide (PBO) is a pesticide synergist. It does not, by itself have pesticidal properties. However, when added to insecticide mixtures, typically pyrethrin, pyrethroid, and carbamate insecticides, their potency is increased considerably.^[1]

Piperonyl butoxide is a potent cytochrome P450 and non-specific esterase inhibitor. This families of these enzymes act as the principal detoxification pathways for many pesticides. Inhibiting the detoxification pathway allows higher unmetabolised systemic concentrations of the active insecticide to remain within the target animal for a longer period.

Piperonyl butoxide is moderately stable, and is a semisynthetic derivative of safrole.

It is debatable whether the substance is oncogenic, mutagenic, or teratogenic in humans. Its acute oral and dermal toxicity in mammals is low ^[2]

[edit] References

1. ^ National Pesticide Information Center - Piperonyl Butoxide General Fact Sheet
2. ^ National Pesticide Information Center - Piperonyl Butoxide Technical Fact Sheet

Moores, G. D., Philippou, D., Borzatta, V., Trincia, P., Jewess, P., Gunning, R., Bingham, G. An analogue of piperonyl butoxide facilitates the characterisation of metabolic resistance. Pest Manag. Sci. 65: 150-154 (2009).

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